Clopidogrel Monotherapy After DAPT — Key Points (SCAI 2026)
Clopidogrel Monotherapy After DAPT — Key Points (SCAI 2026)
• After 12 months of DAPT post-PCI:
P2Y12 monotherapy (clopidogrel) may be superior to aspirin alone
• Death/MI/Stroke:
* Clopidogrel: 1.3%
* Aspirin: 3.0%
• Bleeding :
* Similar between groups
Key Insights
• Benefit more pronounced in:
* High bleeding risk
* Complex PCI
• Supports prior trials:
* HOST-EXAM
* SMART-CHOICE
Limitations
• Observational study
• Predominantly Asian population
📌 Bottom Line
Evidence is accumulating:
Clopidogrel monotherapy may be a better default than aspirin alone after DAPT — but guidelines have not yet changed.
• Source (news): TCTMD coverage of SCAI 2026
• Article date: May 1, 2026
https://www.tctmd.com/news/large-study-lends-support-clopidogrel-monotherapy-after-dapt-cessation?utm_source=chatgpt.com
