{"id":10105,"date":"2026-06-02T14:23:36","date_gmt":"2026-06-02T11:23:36","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=10105"},"modified":"2026-06-02T14:23:36","modified_gmt":"2026-06-02T11:23:36","slug":"a-new-rna-based-therapy-microrna-change-post-mi-remodeling","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/a-new-rna-based-therapy-microrna-change-post-mi-remodeling\/","title":{"rendered":"\u00a0A new RNA-based Therapy (microRNA) Change Post-MI Remodeling?"},"content":{"rendered":"<p><span>\u00a0A new RNA-based Therapy (microRNA) Change Post-MI Remodeling?<\/span><\/p>\n<p><span>Phase 2 HF-REVERT trial tested a new RNA-based therapy designed to block harmful microRNA-132 activity involved in heart remodeling after myocardial infarction.<\/span><br \/>\n<span>* The drug reduced circulating miR-132 levels, confirming biological activity, but did not significantly improve LV remodeling at 6 months.<\/span><br \/>\n<span>* Included:<\/span><br \/>\n<span>* Recent MI<\/span><br \/>\n<span>* LVEF \u2264 45%<\/span><br \/>\n<span>* Safety profile remained acceptable.<\/span><br \/>\n<span>* Published May 10, 2026.<\/span><br \/>\n<a href=\"http:\/\/www.nature.com\/articles\/s41591-026-04408-4\" target=\"_blank\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/www.nature.com\/articles\/s41591-026-04408-4&amp;source=gmail&amp;ust=1780485774434000&amp;usg=AOvVaw2X0OF6x98Bxf-aQg3pouwb\" rel=\"noopener\">http:\/\/www.nature.com\/<wbr \/>articles\/s41591-026-04408-4<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00a0A new RNA-based Therapy (microRNA) Change Post-MI Remodeling? Phase 2 HF-REVERT trial tested a new RNA-based therapy designed to block harmful microRNA-132 activity involved in heart remodeling after myocardial infarction. * The drug reduced circulating miR-132 levels, confirming biological activity, but did not significantly improve LV remodeling at 6 months. * Included: * Recent MI [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-10105","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/10105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=10105"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/10105\/revisions"}],"predecessor-version":[{"id":10106,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/10105\/revisions\/10106"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=10105"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=10105"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=10105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}