{"id":10121,"date":"2026-06-07T00:22:40","date_gmt":"2026-06-06T21:22:40","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=10121"},"modified":"2026-06-07T00:22:40","modified_gmt":"2026-06-06T21:22:40","slug":"nejm-eas-2026-heart-2-trial","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/nejm-eas-2026-heart-2-trial\/","title":{"rendered":"NEJM \/ EAS 2026 \u2013 Heart-2 Trial"},"content":{"rendered":"<p><span>NEJM \/ EAS 2026 \u2013 Heart-2 Trial<\/span><\/p>\n<p><span>VERVE-102, a one-time IV therapy designed to permanently inactivate the PCSK9 gene, reduced LDLby up to 62%, with sustained benefit through 1 year of follow-up.<\/span><\/p>\n<p><span>By preserving LDL receptors in the liver, it enhances clearance of LDL cholesterol from the bloodstream.<\/span><\/p>\n<p><span>Source: NEJM, Heart-2 Phase I Trial, EAS 2026.<\/span><br \/>\n<span>TCTMD Coverage\u2060<\/span><\/p>\n<p><a href=\"https:\/\/www.tctmd.com\/news\/gene-editing-therapy-safely-lowers-pcsk9-ldl-cholesterol-phase-i-heart-2\" target=\"_blank\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/www.tctmd.com\/news\/gene-editing-therapy-safely-lowers-pcsk9-ldl-cholesterol-phase-i-heart-2&amp;source=gmail&amp;ust=1780867334076000&amp;usg=AOvVaw1zi1-QdJIAWPJKrzl_91K0\" rel=\"noopener\">https:\/\/www.tctmd.com\/news\/<wbr \/>gene-editing-therapy-safely-<wbr \/>lowers-pcsk9-ldl-cholesterol-<wbr \/>phase-i-heart-2<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>NEJM \/ EAS 2026 \u2013 Heart-2 Trial VERVE-102, a one-time IV therapy designed to permanently inactivate the PCSK9 gene, reduced LDLby up to 62%, with sustained benefit through 1 year of follow-up. By preserving LDL receptors in the liver, it enhances clearance of LDL cholesterol from the bloodstream. Source: NEJM, Heart-2 Phase I Trial, EAS [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-10121","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/10121","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=10121"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/10121\/revisions"}],"predecessor-version":[{"id":10122,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/10121\/revisions\/10122"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=10121"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=10121"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=10121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}