{"id":10594,"date":"2026-09-21T21:37:39","date_gmt":"2026-09-21T18:37:39","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=10594"},"modified":"2026-09-21T21:37:39","modified_gmt":"2026-09-21T18:37:39","slug":"iv-thrombolysis-4-5-24-hours-after-acute-ischemic-stroke-ean-paper-of-the-month-september-2026","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/iv-thrombolysis-4-5-24-hours-after-acute-ischemic-stroke-ean-paper-of-the-month-september-2026\/","title":{"rendered":"IV Thrombolysis 4.5\u201324 Hours After Acute Ischemic Stroke | EAN Paper of the Month \u2013 September 2026"},"content":{"rendered":"<p>IV Thrombolysis 4.5\u201324 Hours After Acute Ischemic Stroke | EAN Paper of the Month \u2013 September 2026<\/p>\n<p>\u2022\u2060 \u2060Study: Updated systematic review and meta-analysis of 13 studies including 4,867 patients with acute ischemic stroke beyond 4.5 hours or with unknown onset.<br \/>\n\u2022\u2060 \u2060Treatment: 2,456 received IV thrombolysis plus best medical therapy; 2,411 received best medical therapy alone.<br \/>\n\u2022\u2060 \u2060Excellent functional outcome at 90 days (mRS 0\u20131): improved with thrombolysis (RR 1.23; 95% CI 1.15\u20131.33; NNT 13).<br \/>\n\u2022\u2060 \u2060Good functional outcome (mRS 0\u20132): also improved (RR 1.15; 95% CI 1.05\u20131.25).<br \/>\n\u2022\u2060 \u2060Safety: Symptomatic intracranial hemorrhage increased (RR 2.11; NNH 75), but 90-day mortality was not significantly increased.<br \/>\n\u2022\u2060 \u2060Patient selection is key: CT first excludes intracranial hemorrhage, CTA identifies large-vessel occlusion and potential need for thrombectomy, while CT perfusion or MRI can identify patients with limited established infarction and salvageable brain tissue.<br \/>\n\u2022\u2060 \u2060Clinical message: The 4.5-hour window is not an absolute barrier in appropriately selected patients; advanced imaging can identify those who may still benefit from IV thrombolysis.<\/p>\n<p>Source: European Academy of Neurology (EAN), Research Paper of the Month, September 7, 2026<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"lC2V87299b\"><p><a href=\"https:\/\/www.eanpages.org\/2026\/09\/07\/research-paper-of-the-month-iv-thrombolysis-in-the-extended-time-window-for-acute-ischemic-stroke-an-updated-systematic-review-and-meta-analysis\/\">Research Paper of the Month: IV Thrombolysis in the Extended Time Window for Acute Ischemic Stroke: An Updated Systematic Review and Meta-Analysis<\/a><\/p><\/blockquote>\n<p><iframe class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"\u201cResearch Paper of the Month: IV Thrombolysis in the Extended Time Window for Acute Ischemic Stroke: An Updated Systematic Review and Meta-Analysis\u201d \u2014 eanNews\" src=\"https:\/\/www.eanpages.org\/2026\/09\/07\/research-paper-of-the-month-iv-thrombolysis-in-the-extended-time-window-for-acute-ischemic-stroke-an-updated-systematic-review-and-meta-analysis\/embed\/#?secret=dXDZAa3bFd#?secret=lC2V87299b\" data-secret=\"lC2V87299b\" width=\"500\" height=\"282\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>IV Thrombolysis 4.5\u201324 Hours After Acute Ischemic Stroke | EAN Paper of the Month \u2013 September 2026 \u2022\u2060 \u2060Study: Updated systematic review and meta-analysis of 13 studies including 4,867 patients with acute ischemic stroke beyond 4.5 hours or with unknown onset. \u2022\u2060 \u2060Treatment: 2,456 received IV thrombolysis plus best medical therapy; 2,411 received best medical [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-10594","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/10594","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=10594"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/10594\/revisions"}],"predecessor-version":[{"id":10595,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/10594\/revisions\/10595"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=10594"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=10594"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=10594"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}