LATE-MT Trial \u2014 Mechanical Thrombectomy 24 to 72 Hours after Large-Vessel Ischemic Stroke<\/p>\n
* RCT: 336 patients at 35 stroke centers in China with anterior-circulation LVO.
\n* Thrombectomy benefit is established within 24 h;
\nLATE-MT trial tested whether benefit extends to 24\u201372 h when salvageable brain tissue remains.
\n* Thrombectomy improved 90-day functional outcome; disability\/death: 52% vs 65% with medical therapy alone.
\n* Safety: symptomatic ICH 4.8% vs 0%; mortality 6.0% vs 1.8%\u2014a concerning numerical increase, but not statistically significant.
\n* Practical approach (first 24 h): CTA\/MRA confirms LVO \u2192 \u22646 h: proceed rapidly to thrombectomy; 6\u201324 h: select patients based on salvageable brain tissue on imaging.
\nSelected patients may benefit even 24\u201372 h after stroke if viable penumbra remains. CT perfusion + automated software identify salvageable tissue (core <50 mL, mismatch \u22651.8, penumbra \u226515 mL).<\/p>\n
Source: NEJM, Oct 23, 2026<\/p>\n
https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2609362<\/a><\/p>\n <\/p>\n