{"id":6039,"date":"2025-03-19T16:50:22","date_gmt":"2025-03-19T13:50:22","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=6039"},"modified":"2025-03-19T16:50:22","modified_gmt":"2025-03-19T13:50:22","slug":"lpa-and-ldl-c-are-independent-and-additive-predictors-of-ascvd-risk","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/lpa-and-ldl-c-are-independent-and-additive-predictors-of-ascvd-risk\/","title":{"rendered":"Lp(a) and LDL-c are independent and Additive Predictors of ASCVD Risk"},"content":{"rendered":"<div>Lp(a) and LDL-c are independent and Additive Predictors of ASCVD Risk.<\/div>\n<div><\/div>\n<div>\ud83d\udcc5 Highlighted by AHA: March 11, 2025<\/div>\n<div>\ud83d\udcc4 Source: Circulation<\/div>\n<div>\ud83d\udcd1 Study: Bhatia HS, Wandel S, Willeit P, et. A Participant-Level Meta-Analysis. Circulation. 2025.<\/div>\n<div><\/div>\n<div>Key Findings:<\/div>\n<div><span> \u2022 Independent Risk Factors: Baseline LDL-c and Lp(a) levels were independently associated with increased ASCVD risk.<\/span><\/div>\n<div><span> \u2022 Additive Effect: Patients with high levels of both LDL-c and Lp(a) had the highest ASCVD risk.<\/span><\/div>\n<div><span> \u2022 Statin-Treated Patients:<\/span><\/div>\n<div><span> \u2022 Elevated Lp(a) levels remained associated with ASCVD risk regardless of LDL-c reduction.<\/span><\/div>\n<div><span> \u2022 LDL-c levels alone were not significantly associated with ASCVD risk in statin-treated patients.<\/span><\/div>\n<div><span> \u2022 Meta-Analysis Details:<\/span><\/div>\n<div><span> \u2022 Included six randomized controlled statin trials (4D, 4S, CARDS, JUPITER, LIPID, MIRACL).<\/span><\/div>\n<div><span> \u2022 Data from 27,658 participants with a median follow-up of 2.8 years.<\/span><\/div>\n<div><span> \u2022 Baseline Lp(a) vs. Achieved LDL-c:<\/span><\/div>\n<div><span> \u2022 ASCVD risk was highest in patients with Lp(a) &gt;50 mg\/dL and LDL-c in the highest quartile (&gt;140.8 mg\/dL).<\/span><\/div>\n<div><span> \u2022 Even in patients achieving the lowest LDL-c levels (&lt;77.3 mg\/dL), those with Lp(a) &gt;50 mg\/dL had a higher ASCVD risk.<\/span><\/div>\n<div><span> \u2022 Clinical Implication:<\/span><\/div>\n<div><span> \u2022 Lowering LDL-c alone does not eliminate Lp(a)-related cardiovascular risk.<\/span><\/div>\n<div><span> \u2022 The findings highlight the need for Lp(a) testing and its integration into cardiovascular risk assessment.<\/span><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Lp(a) and LDL-c are independent and Additive Predictors of ASCVD Risk. \ud83d\udcc5 Highlighted by AHA: March 11, 2025 \ud83d\udcc4 Source: Circulation \ud83d\udcd1 Study: Bhatia HS, Wandel S, Willeit P, et. A Participant-Level Meta-Analysis. Circulation. 2025. Key Findings: \u2022 Independent Risk Factors: Baseline LDL-c and Lp(a) levels were independently associated with increased ASCVD risk. \u2022 Additive [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6039","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/6039","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=6039"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/6039\/revisions"}],"predecessor-version":[{"id":6040,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/6039\/revisions\/6040"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=6039"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=6039"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=6039"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}