{"id":6367,"date":"2025-04-13T14:08:56","date_gmt":"2025-04-13T11:08:56","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=6367"},"modified":"2025-04-13T14:08:56","modified_gmt":"2025-04-13T11:08:56","slug":"fluid-restriction-does-not-improve-outcomes-in-chronic-hf","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/fluid-restriction-does-not-improve-outcomes-in-chronic-hf\/","title":{"rendered":"Fluid Restriction Does Not Improve outcomes in Chronic HF."},"content":{"rendered":"
Fluid Restriction Does Not Improve outcomes in Chronic HF.<\/div>\n
Source: ACC.25 Scientific Session,<\/div>\n
Date: April 1, 2025<\/div>\n
Summary of Fluid Restriction in Heart Failure vs. Liberal Fluid Uptake – FRESH-UP trial :<\/div>\n
1. Background:<\/span><\/div>\n
\u2022 Fluid restriction is commonly recommended for chronic heart failure (HF) patients, though evidence from randomized controlled trials (RCTs) has been limited.<\/span><\/div>\n
\u2022 The potential negative impact on quality of life (QoL) and patient comfort is a concern.<\/span><\/div>\n
2. Study Design \u2013 FRESH-UP Trial:<\/span><\/div>\n
\u2022 Multicenter, open-label RCT in the Netherlands.<\/span><\/div>\n
\u2022 504 patients with NYHA class II\u2013III chronic HF symptoms.<\/span><\/div>\n
\u2022 Randomized to:<\/span><\/div>\n
\u2022 Liberal fluid intake,<\/span><\/div>\n
\u2022 Or fluid restriction (1.5 L\/day) for 3 months.<\/span><\/div>\n
\u2022 Primary endpoint: QoL via KCCQ-OSS (Kansas City Cardiomyopathy Questionnaire \u2013 Overall Summary Score).<\/span><\/div>\n
\u2022 Secondary endpoint: Thirst distress via Thirst Distress Scale for HF (TDS-HF).<\/span><\/div>\n
\u2022 Safety endpoints: Mortality, HF hospitalization, IV diuretic use at 3 and 6 months.<\/span><\/div>\n
3. Main Results:<\/span><\/div>\n
\u2022 Quality of Life (KCCQ-OSS):<\/span><\/div>\n
\u2022 Liberal group: 74.0 (95%CI: 71.5\u201376.6)<\/span><\/div>\n
\u2022 Fluid restriction: 72.2 (95%CI: 69.6\u201374.7)<\/span><\/div>\n
\u2022 Mean difference: +2.17 points (95%CI: \u20130.06 to 4.39; P=0.06) \u2014 not statistically significant.<\/span><\/div>\n
\u2022 Thirst Distress (TDS-HF):<\/span><\/div>\n
\u2022 Higher in fluid restriction group: 18.6 vs. 16.9 \u2014 P<0.001<\/span><\/div>\n
\u2022 Safety outcomes:<\/span><\/div>\n
\u2022 No significant differences in mortality, hospitalization, or diuretic use at 6 months (all P>0.05)<\/span><\/div>\n
4. Conclusion:<\/span><\/div>\n
\u2022 Restricting fluid intake to 1.5 L\/day in chronic HF did not improve QoL.<\/span><\/div>\n
\u2022 Patients experienced significantly more thirst.<\/span><\/div>\n
\u2022 No safety concerns were identified.<\/span><\/div>\n
\u2022 The study challenges the clinical benefit of fluid restriction in chronic HF management.<\/span><\/div>\n
<\/div>\n
<\/div>\n","protected":false},"excerpt":{"rendered":"

Fluid Restriction Does Not Improve outcomes in Chronic HF. Source: ACC.25 Scientific Session, Date: April 1, 2025 Summary of Fluid Restriction in Heart Failure vs. Liberal Fluid Uptake – FRESH-UP trial : 1. Background: \u2022 Fluid restriction is commonly recommended for chronic heart failure (HF) patients, though evidence from randomized controlled trials (RCTs) has been […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6367","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/6367","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=6367"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/6367\/revisions"}],"predecessor-version":[{"id":6368,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/6367\/revisions\/6368"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=6367"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=6367"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=6367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}