{"id":6653,"date":"2025-05-05T12:41:04","date_gmt":"2025-05-05T09:41:04","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=6653"},"modified":"2025-05-05T12:41:04","modified_gmt":"2025-05-05T09:41:04","slug":"summary-one-time-ldl-c-hs-crp-and-lpa-testing-predicts-long-term-mace-risk","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/summary-one-time-ldl-c-hs-crp-and-lpa-testing-predicts-long-term-mace-risk\/","title":{"rendered":"Summary: One-Time LDL-c, hs-CRP, and Lp(a) Testing Predicts Long-Term MACE Risk"},"content":{"rendered":"<p>Summary: One-Time LDL-c, hs-CRP, and Lp(a) Testing Predicts Long-Term MACE Risk<br \/>\nSource: European Heart Journal<br \/>\nPublished: April 10, 2025<br \/>\nDOI: 10.1093\/eurheartj\/ehaf209<\/p>\n<p>Key Findings :<br \/>\n1. Study Population:<br \/>\n\u2022 17,087 initially healthy European adults (men and women) from the EPIC-Norfolk study.<br \/>\n\u2022 Enrolled between 1993\u20131997 with median follow-up of 20.5 years.<br \/>\n2. Objective:<br \/>\n\u2022 Assess whether a one-time measurement of LDL-c, hs-CRP, and Lp(a) predicts future major adverse cardiovascular events (MACE).<br \/>\n3. Primary Outcome:<br \/>\n\u2022 First occurrence of MACE, defined as fatal\/nonfatal coronary artery disease or ischemic stroke.<br \/>\n4. Sex Differences in Risk:<br \/>\n\u2022 Men had higher MACE risk from all biomarkers compared to women.<br \/>\n\u2022 Example (LDL-c): Men HR 1.91 (Hazard Ratio,see definition below*) vs. Women HR = 1.46<br \/>\n5. Combined Biomarker Risk:<br \/>\n\u2022 1 elevated biomarker: HR = 1.33.<br \/>\n\u2022 2 elevated biomarkers: HR = 1.68.<br \/>\n\u2022 All 3 elevated: HR = 2.41<br \/>\n7. Conclusion:<br \/>\n\u2022 A single, one-time measurement of LDL-c, hs-CRP, and Lp(a) is a strong predictor of long-term MACE risk in healthy individuals.<br \/>\n\u2022 Authors advocate for universal screening using these 3 biomarkers for both primary and secondary prevention.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1093\/eurheartj\/ehaf209\">https:\/\/doi.org\/10.1093\/eurheartj\/ehaf209<\/a><\/p>\n<p>*What is HR \u201cHazard Ratio\u201d?<br \/>\nThe Hazard Ratio (HR) is a measure used in medical research to compare the risk of an event happening (like heart attack, stroke, or death) between two groups over time. How to interpret it:<br \/>\n\u2022 HR = 1.0 \u2192 No difference in risk between the two groups.<br \/>\n\u2022 HR &gt; 1.0 \u2192 Higher risk in the group being studied.<br \/>\n(e.g., HR = 1.50 means 50% higher risk)<br \/>\n\u2022 HR &lt; 1.0 \u2192 Lower risk in the group being studied.<br \/>\n(e.g., HR = 0.75 means 25% lower risk)<br \/>\nExample:<br \/>\nIf a study reports that people with high LDL-c have an HR of 1.78 for stroke, this means they have a 78% higher risk of having a stroke compared to those with low LDL-c.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: One-Time LDL-c, hs-CRP, and Lp(a) Testing Predicts Long-Term MACE Risk Source: European Heart Journal Published: April 10, 2025 DOI: 10.1093\/eurheartj\/ehaf209 Key Findings : 1. Study Population: \u2022 17,087 initially healthy European adults (men and women) from the EPIC-Norfolk study. \u2022 Enrolled between 1993\u20131997 with median follow-up of 20.5 years. 2. Objective: \u2022 Assess whether [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6653","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/6653","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=6653"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/6653\/revisions"}],"predecessor-version":[{"id":6654,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/6653\/revisions\/6654"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=6653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=6653"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=6653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}