{"id":7600,"date":"2025-06-25T17:49:37","date_gmt":"2025-06-25T14:49:37","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=7600"},"modified":"2025-06-25T17:49:37","modified_gmt":"2025-06-25T14:49:37","slug":"two-step-strategy-simplifies-hfpef-diagnosis-with-high-accuracy","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/two-step-strategy-simplifies-hfpef-diagnosis-with-high-accuracy\/","title":{"rendered":"Two-Step Strategy Simplifies HFpEF Diagnosis with High Accuracy"},"content":{"rendered":"<div>Two-Step Strategy Simplifies HFpEF Diagnosis with High Accuracy<\/div>\n<div><\/div>\n<div>Published: June 9, 2025<\/div>\n<div><\/div>\n<div>1.<span> <\/span>Topline Finding<\/div>\n<div><span> \u2022 A simplified two-step approach using left atrial volume indexed by height\u00b2 (LAViH\u00b2) and natriuretic peptides (NP) accurately identifies HFpEF and helps avoid unnecessary testing in many patients.<\/span><\/div>\n<div><span> \u2022 Yields 88% specificity and 97% positive predictive value, reducing need for additional testing.<\/span><\/div>\n<div><span> 2. How It Works<\/span><\/div>\n<div><span> \u2022 Step 1: Measure LAViH2 via echocardiography (cut-off &gt;35.5 mL\/m\u00b2 in sinus rhythm, &gt;38.6 in AF).<\/span><\/div>\n<div><span> \u2022 Step 2: Check NP levels based on HFA-PEFF major criteria.<\/span><\/div>\n<div><span> \u2022 If both are abnormal, HFpEF can be \u201cruled in\u201d with high confidence.<\/span><\/div>\n<div><span> 3. Clinical Impact<\/span><\/div>\n<div><span> \u2022 Identified 60% of HFpEF patients accurately in derivation cohort; validation cohorts showed similar accuracy.<\/span><\/div>\n<div><span> \u2022 Reduced intermediate diagnostic classifications (HFA-PEFF \/ H2FPEF) by 21%\u201357%.<\/span><\/div>\n<div><span> \u2022 Approach is flexible\u2014LA reservoir strain may be used as an alternative to volume.<\/span><\/div>\n<div><span> 4. In Practice<\/span><\/div>\n<div><span> \u2022 The method can serve as a first step before using full scoring systems like HFA-PEFF or H\u2082FPEF, saving time and resources.<\/span><\/div>\n<div><\/div>\n<div><a href=\"https:\/\/click.mail.medscape.com\/?qs=fffafbc1f0c360d6f6a8d756be81b748f326a741111ca683e2aaeffd97d1ed4ad33c154a425e650ab21a1b260e23c9de2bb4bd8301e32fff918da0282ac054ff\">https:\/\/click.mail.medscape.com\/?qs=fffafbc1f0c360d6f6a8d756be81b748f326a741111ca683e2aaeffd97d1ed4ad33c154a425e650ab21a1b260e23c9de2bb4bd8301e32fff918da0282ac054ff<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Two-Step Strategy Simplifies HFpEF Diagnosis with High Accuracy Published: June 9, 2025 1. Topline Finding \u2022 A simplified two-step approach using left atrial volume indexed by height\u00b2 (LAViH\u00b2) and natriuretic peptides (NP) accurately identifies HFpEF and helps avoid unnecessary testing in many patients. \u2022 Yields 88% specificity and 97% positive predictive value, reducing need for [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7600","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=7600"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7600\/revisions"}],"predecessor-version":[{"id":7608,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7600\/revisions\/7608"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=7600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=7600"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=7600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}