{"id":7672,"date":"2025-06-27T16:42:47","date_gmt":"2025-06-27T13:42:47","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=7672"},"modified":"2025-06-27T16:42:47","modified_gmt":"2025-06-27T13:42:47","slug":"symptoms-dont-always-indicate-the-severity-of-coronary-artery-disease","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/symptoms-dont-always-indicate-the-severity-of-coronary-artery-disease\/","title":{"rendered":"Symptoms Don\u2019t Always Indicate the Severity of Coronary Artery Disease"},"content":{"rendered":"<div>Symptoms Don\u2019t Always Indicate the Severity of Coronary Artery Disease<\/div>\n<div>Date: June 18, 2025<\/div>\n<div>Source: JACC: Cardiovascular Imaging.<\/div>\n<div><\/div>\n<div>Scientific Summary (Key Points):<\/div>\n<div><span> 1. Study Focus:<\/span><\/div>\n<div>New research shows that coronary artery disease (CAD) symptoms are not always reliable indicators of the actual severity of atherosclerosis or stenosis.<\/div>\n<div><span> 2. Lead Author:<\/span><\/div>\n<div>Dr. Jonathon Leipsic, St. Paul\u2019s Hospital, Vancouver.<\/div>\n<div><span> 3. Study Design:<\/span><\/div>\n<div><span> \u2022 Data from ADVANCE registry: 4,382 patients.<\/span><\/div>\n<div><span> \u2022 Patients grouped by symptoms:<\/span><\/div>\n<div>\u25aa 1079 asymptomatic<\/div>\n<div>\u25aa 438 with dyspnea<\/div>\n<div>\u25aa 277 with noncardiac chest pain<\/div>\n<div>\u25aa 1621 with atypical chest pain<\/div>\n<div>\u25aa 967 with typical angina<\/div>\n<div><span> \u2022 Tools used:<\/span><\/div>\n<div>\u25aa AI-based plaque quantification (Total Percentage Atheroma Volume &#8211; TPAV)<\/div>\n<div>\u25aa FFR-CT to assess functional significance of stenosis.<\/div>\n<div><span> 4. Key Findings:<\/span><\/div>\n<div><span> \u2022 No consistent correlation between symptoms and either TPAV or FFR-CT.<\/span><\/div>\n<div><span> \u2022 Typical angina was associated with more plaque and abnormal FFR-CT.<\/span><\/div>\n<div><span> \u2022 Atypical or noncardiac pain and dyspnea showed weak or inverse correlations.<\/span><\/div>\n<div><span> \u2022 Even asymptomatic patients could have significant atherosclerosis.<\/span><\/div>\n<div><span> 5. Clinical Implications:<\/span><\/div>\n<div><span> \u2022 Symptoms alone are not reliable to guide decisions in CAD.<\/span><\/div>\n<div><span> \u2022 Reliance on symptom-based assessment may lead to missed diagnoses or under-treatment.<\/span><\/div>\n<div><span> 6. Expert Opinion \u2013 Dr. Matthew Budoff (UCLA):<\/span><\/div>\n<div><span> \u2022 Reinforces the importance of CT angiography in early diagnosis.<\/span><\/div>\n<div><span> \u2022 Supports the 2021 AHA\/ACC chest pain guidelines recommending CT as a first-line tool.<\/span><\/div>\n<div><span> \u2022 Emphasizes the need to assess plaque burden, not just symptoms or stenosis.<\/span><\/div>\n<div><\/div>\n<div>7.<span> <\/span>Clinical Role of Symptoms (Clarification):<\/div>\n<div>Despite the weak correlation found between symptoms and plaque burden or FFR-CT, symptoms remain a key component of clinical assessment. According to the AHA\/ACC &amp; ESC Chest Pain Guidelines, evaluating symptom type and severity\u2014particularly typical angina\u2014is crucial for risk stratification, determining urgency of testing, and guiding further diagnostic or therapeutic steps. Symptoms should be interpreted in context, alongside imaging and risk scores.<\/div>\n<div><\/div>\n<div><a href=\"https:\/\/doi.org\/10.1016\/j.jcmg.2025.05.002\">https:\/\/doi.org\/10.1016\/j.jcmg.2025.05.002<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Symptoms Don\u2019t Always Indicate the Severity of Coronary Artery Disease Date: June 18, 2025 Source: JACC: Cardiovascular Imaging. Scientific Summary (Key Points): 1. Study Focus: New research shows that coronary artery disease (CAD) symptoms are not always reliable indicators of the actual severity of atherosclerosis or stenosis. 2. Lead Author: Dr. Jonathon Leipsic, St. Paul\u2019s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7672","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7672","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=7672"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7672\/revisions"}],"predecessor-version":[{"id":7676,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7672\/revisions\/7676"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=7672"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=7672"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=7672"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}