{"id":7695,"date":"2025-06-27T16:57:25","date_gmt":"2025-06-27T13:57:25","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=7695"},"modified":"2025-06-27T16:57:25","modified_gmt":"2025-06-27T13:57:25","slug":"early-aggressive-blood-pressure-lowering-tied-to-better-intracerebral-hemorrhage-ich-outcomes","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/early-aggressive-blood-pressure-lowering-tied-to-better-intracerebral-hemorrhage-ich-outcomes\/","title":{"rendered":"Early, Aggressive Blood Pressure Lowering Tied to Better Intracerebral Hemorrhage( ICH) Outcomes"},"content":{"rendered":"<div>Early, Aggressive Blood Pressure Lowering Tied to Better Intracerebral Hemorrhage( ICH) Outcomes<\/div>\n<div>Source: Medscape June 19, 2025 | -Published in -The Lancet June 18, 2025<\/div>\n<div><\/div>\n<div>Key Findings (Pooled Analysis \u2013 INTERACT1\u20134 Trials):<\/div>\n<div><\/div>\n<div><span> 1. Early intensive BP lowering within 3 hours of ICH symptom onset is associated with:<\/span><\/div>\n<div><span> \u2022 Improved neurological recovery<\/span><\/div>\n<div><span> \u2022 Lower rates of death<\/span><\/div>\n<div><span> \u2022 Fewer serious adverse events<\/span><\/div>\n<div><span> 2. Treatment groups:<\/span><\/div>\n<div><span> \u2022 Intensive group target: SBP &lt;140 mm Hg within 1 hour<\/span><\/div>\n<div><span> \u2022 Standard guideline group: SBP &lt;180 mm Hg within 1 hour<\/span><\/div>\n<div><span> 3. Study population:<\/span><\/div>\n<div><span> \u2022 More than 11,000 patients across four randomized trials (INTERACT1\u20134)<\/span><\/div>\n<div><span> \u2022 All had acute ICH with SBP &gt;150 mm Hg<\/span><\/div>\n<div><span> 4. Outcomes:<\/span><\/div>\n<div><span> \u2022 Better functional recovery (lower modified Rankin scores)<\/span><\/div>\n<div><span> \u2022 Reduced neurological deterioration within 7 days (OR = 0.76)<\/span><\/div>\n<div><span> \u2022 Fewer serious adverse events (OR = 0.84)<\/span><\/div>\n<div><span> \u2022 Lower mortality (OR = 0.83)<\/span><\/div>\n<div><span> 5. CT sub-analysis (~3,000 patients):<\/span><\/div>\n<div><span> \u2022 No significant change in hematoma size overall<\/span><\/div>\n<div><span> \u2022 But 25% of patients treated within 3 hours had reduced hematoma growth<\/span><\/div>\n<div><span> 6. Editorial insight:<\/span><\/div>\n<div><span> \u2022 Dr. David Werring emphasized the timing difference between ischemic stroke and ICH<\/span><\/div>\n<div><span> \u2022 Early BP lowering may reduce hematoma expansion, a key driver of poor outcomes in ICH<\/span><\/div>\n<div><span> \u2022 Still, potential risks and confounding variables (especially in INTERACT3) require further study<\/span><\/div>\n<div><\/div>\n<div>Takeaway:<\/div>\n<div><\/div>\n<div>Ischemic stroke:<\/div>\n<div><\/div>\n<div><span> \u2022 Be cautious with early BP lowering.<\/span><\/div>\n<div><span> \u2022 Preserve cerebral perfusion.<\/span><\/div>\n<div><\/div>\n<div>Hemorrhagic stroke (ICH):<\/div>\n<div><\/div>\n<div><span> \u2022 Early intensive BP lowering (within 3 hours) is beneficial.<\/span><\/div>\n<div><span> \u2022 Reduces risk of hematoma expansion and improves neurological outcomes.<\/span><\/div>\n<div><\/div>\n<div>Conclusion:<\/div>\n<div>\u201cEarlier is better \u2014 once again, time is brain for ICH.\u201d<\/div>\n<div>Ultra-early intensive BP reduction appears safe and beneficial, especially within the first 3 hours.<\/div>\n<div><a href=\"https:\/\/www.medscape.com\/viewarticle\/1000914\">https:\/\/www.medscape.com\/viewarticle\/1000914<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Early, Aggressive Blood Pressure Lowering Tied to Better Intracerebral Hemorrhage( ICH) Outcomes Source: Medscape June 19, 2025 | -Published in -The Lancet June 18, 2025 Key Findings (Pooled Analysis \u2013 INTERACT1\u20134 Trials): 1. Early intensive BP lowering within 3 hours of ICH symptom onset is associated with: \u2022 Improved neurological recovery \u2022 Lower rates of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7695","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7695","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=7695"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7695\/revisions"}],"predecessor-version":[{"id":7699,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7695\/revisions\/7699"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=7695"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=7695"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=7695"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}