{"id":7705,"date":"2025-06-27T17:00:21","date_gmt":"2025-06-27T14:00:21","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=7705"},"modified":"2025-06-27T17:00:21","modified_gmt":"2025-06-27T14:00:21","slug":"cardiorenal-syndrome-in-adults-with-congenital-heart-disease","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/cardiorenal-syndrome-in-adults-with-congenital-heart-disease\/","title":{"rendered":"Cardiorenal Syndrome in Adults with Congenital Heart Disease"},"content":{"rendered":"<div>Cardiorenal Syndrome in Adults with Congenital Heart Disease<\/div>\n<div>Journal: Journal of Clinical Medicine (MDPI) \u2013 Published 20 June 2025<\/div>\n<div><\/div>\n<div>Key Insights:<\/div>\n<div><span> 1. Population Studied:<\/span><\/div>\n<div>Adults with congenital heart disease (ACHD) featuring:<\/div>\n<div><span> \u2022 Systemic right ventricle (e.g. d-TGA, ccTGA)<\/span><\/div>\n<div><span> \u2022 Subpulmonary right ventricle (e.g. TOF, Eisenmenger)<\/span><\/div>\n<div><span> \u2022 Fontan circulation<\/span><\/div>\n<div><span> 2. Prevalence of Renal Dysfunction:<\/span><\/div>\n<div><span> \u2022 30\u201350% of ACHD patients have reduced eGFR (&lt;90\u202fmL\/min\/1.73\u202fm\u00b2)<\/span><\/div>\n<div><span> \u2022 Up to 9\u201310% display moderate\u2013severe CKD (&lt;60\u202fmL\/min)\u00a0 \ufffc<\/span><\/div>\n<div><span> 3. Pathophysiology:<\/span><\/div>\n<div><span> \u2022 Chronic hemodynamic stress: low cardiac output, high central venous pressure<\/span><\/div>\n<div><span> \u2022 Neurohormonal activation<\/span><\/div>\n<div><span> \u2022 Repeated surgeries and hypoxemia contribute to renal injury\u00a0 \ufffc<\/span><\/div>\n<div><span> 4. Biomarkers for Early Detection:<\/span><\/div>\n<div><span> \u2022 Albuminuria, cystatin C, and eGFR are vital for monitoring CRS<\/span><\/div>\n<div><span> \u2022 NT-proBNP correlates with cardiac and renal function decline\u00a0 \ufffc<\/span><\/div>\n<div><span> 5. Management Strategies:<\/span><\/div>\n<div><span> \u2022 Early detection and tailored heart failure therapy<\/span><\/div>\n<div><span> \u2022 Volume control, neurohormonal blockade (ACEi\/ARBs), diuretics<\/span><\/div>\n<div><span> \u2022 Consideration for transplant evaluation when end-organ damage is irreversible\u00a0 \ufffc<\/span><\/div>\n<div><span> 6. Significance:<\/span><\/div>\n<div><span> \u2022 Highlights a frequently under\u2011recognized CRS subtype<\/span><\/div>\n<div><span> \u2022 Offers a call for cardiologists and nephrologists to adopt multidisciplinary approaches in ACHD care<\/span><\/div>\n<div><\/div>\n<div>Conclusion:<\/div>\n<div><\/div>\n<div>Cardiorenal syndrome in ACHD is common and driven by unique hemodynamic factors. Early biomarker-based detection and tailored, collaborative management are key to improving outcomes in this growing patient group.<\/div>\n<div><a href=\"https:\/\/www.mdpi.com\/2077-0383\/14\/13\/4392\">https:\/\/www.mdpi.com\/2077-0383\/14\/13\/4392<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Cardiorenal Syndrome in Adults with Congenital Heart Disease Journal: Journal of Clinical Medicine (MDPI) \u2013 Published 20 June 2025 Key Insights: 1. Population Studied: Adults with congenital heart disease (ACHD) featuring: \u2022 Systemic right ventricle (e.g. d-TGA, ccTGA) \u2022 Subpulmonary right ventricle (e.g. TOF, Eisenmenger) \u2022 Fontan circulation 2. Prevalence of Renal Dysfunction: \u2022 30\u201350% [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7705","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7705","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=7705"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7705\/revisions"}],"predecessor-version":[{"id":7709,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7705\/revisions\/7709"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=7705"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=7705"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=7705"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}