{"id":7959,"date":"2025-07-17T13:10:39","date_gmt":"2025-07-17T10:10:39","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=7959"},"modified":"2025-07-17T13:12:02","modified_gmt":"2025-07-17T10:12:02","slug":"7959","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/7959\/","title":{"rendered":"Could Pacemakers Help Control Blood Pressure? AVIM therapy: A New Horizon in Blood Pressure Control"},"content":{"rendered":"<div>Could Pacemakers Help Control Blood Pressure? AVIM therapy: A New Horizon in Blood Pressure Control<\/div>\n<div><\/div>\n<div><span> 1. AVIM Therapy \u2013 A Novel Approach:<\/span><\/div>\n<div>Atrioventricular Interval Modulation (AVIM) is a pacing-based therapy delivered via dual-chamber pacemakers. It targets blood pressure reduction by modulating cardiac conduction intervals \u2014 without relying on medications.<\/div>\n<div><span> 2. Clinical Need:<\/span><\/div>\n<div>Designed for patients with uncontrolled hypertension, particularly those who:<\/div>\n<div>\u2013 Fail medication<\/div>\n<div>\u2013 Struggle with adherence<\/div>\n<div>\u2013 Experience drug intolerance<\/div>\n<div><span> 3. FDA Breakthrough Status (April 2025):<\/span><\/div>\n<div>The BackBeat device by Orchestra BioMed, developed in partnership with Medtronic, received breakthrough designation. It\u2019s being studied in patients with hypertension and preserved LVEF.<\/div>\n<div><span> 4. Evidence \u2013 MODERATO II Trial:<\/span><\/div>\n<div>\u2013 11.1 mm Hg reduction in 24-hour systolic BP at 6 months<\/div>\n<div>\u2013 8.1 mm Hg more than medication-only group (P &lt; .001)<\/div>\n<div>\u2013 Older adults with isolated systolic hypertension showed the most promise<\/div>\n<div><span> 5. Advantages:<\/span><\/div>\n<div>\u2013 No dependence on patient adherence<\/div>\n<div>\u2013 Minimal added risk for those already needing pacemakers<\/div>\n<div>\u2013 Could reduce long-term cardiovascular events<\/div>\n<div><span> 6. Limitations &amp; Caution:<\/span><\/div>\n<div>\u2013 Not yet approved for patients without pacing indications<\/div>\n<div>\u2013 Device implantation carries infection and procedural risks<\/div>\n<div><span> 7. Ongoing Trials:<\/span><\/div>\n<div>\u2013 The BACKBEAT study (randomised, double-blinded) is enrolling 500+ patients<\/div>\n<div><\/div>\n<div>Bottom Line:<\/div>\n<div>AVIM therapy may offer a promising nonpharmacologic solution for treatment-resistant hypertension \u2014 especially for older, complex patients \u2014 but widespread use depends on further evidence and ethical oversight.<\/div>\n<div><\/div>\n<div><\/div>\n<div><a href=\"https:\/\/click.mail.medscape.com\/?qs=17d5d5fe9d25d5b865bfae6f4cc1264d1ec9364596da0a30fb8911218215dbbec015fb788562b3a301ac3973d46d76fd69398076371d44a93ef2a0b6cbffb6f6\">https:\/\/click.mail.medscape.com\/?qs=17d5d5fe9d25d5b865bfae6f4cc1264d1ec9364596da0a30fb8911218215dbbec015fb788562b3a301ac3973d46d76fd69398076371d44a93ef2a0b6cbffb6f6<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Could Pacemakers Help Control Blood Pressure? AVIM therapy: A New Horizon in Blood Pressure Control 1. AVIM Therapy \u2013 A Novel Approach: Atrioventricular Interval Modulation (AVIM) is a pacing-based therapy delivered via dual-chamber pacemakers. It targets blood pressure reduction by modulating cardiac conduction intervals \u2014 without relying on medications. 2. Clinical Need: Designed for patients [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7959","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7959","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=7959"}],"version-history":[{"count":3,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7959\/revisions"}],"predecessor-version":[{"id":7962,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/7959\/revisions\/7962"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=7959"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=7959"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=7959"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}