{"id":8030,"date":"2025-07-21T12:50:48","date_gmt":"2025-07-21T09:50:48","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=8030"},"modified":"2025-07-21T12:50:48","modified_gmt":"2025-07-21T09:50:48","slug":"ai-can-detect-cardiac-amyloidosis-from-echo-videos-2","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/ai-can-detect-cardiac-amyloidosis-from-echo-videos-2\/","title":{"rendered":"AI Can Detect Cardiac Amyloidosis from Echo Videos"},"content":{"rendered":"<p><span>AI Can Detect Cardiac Amyloidosis from Echo Videos<\/span><\/p>\n<p><span>Source: European Heart Journal | July 17, 2025<\/span><br \/>\n<span>1. Overview of the Condition<\/span><br \/>\n<span>\u2022 Cardiac amyloidosis occurs when misfolded proteins deposit in the heart, leading to thickened walls and impaired function.<\/span><br \/>\n<span>\u2022 It mimics hypertensive heart disease and aortic stenosis, making diagnosis difficult, especially in early stages.<\/span><br \/>\n<span>2. Diagnostic Challenges<\/span><br \/>\n<span>\u2022 Early stages may not show wall thickening on standard echocardiography.<\/span><br \/>\n<span>\u2022 Symptoms such as fatigue, ankle swelling, and shortness of breath are nonspecific.<\/span><br \/>\n<span>\u2022 Traditional diagnosis requires biopsy or blood\/urine tests.<\/span><br \/>\n<span>3. Rising Prevalence<\/span><br \/>\n<span>\u2022 From 2000 to 2012, prevalence rose from 8 to 17 per 100,000 person-years.<\/span><br \/>\n<span>\u2022 A 2025 Mayo Clinic study found a 1.25% prevalence among &gt;30,000 echo patients, with highest incidence in ages 80\u201389.<\/span><br \/>\n<span>4. Delayed Diagnosis<\/span><br \/>\n<span>\u2022 Many patients face diagnostic delays over a year, worsening outcomes and limiting treatment effectiveness.<\/span><br \/>\n<span>5. AI-Based Screening Tool (EchoGo Amyloidosis)<\/span><br \/>\n<span>\u2022 Developed by Mayo Clinic &amp; Ultromics.<\/span><br \/>\n<span>\u2022 FDA-approved in 2024.<\/span><br \/>\n<span>\u2022 Uses echocardiogram videos to detect cardiac amyloidosis.<\/span><br \/>\n<span>6. Study Design<\/span><br \/>\n<span>\u2022 Retrospective multicenter validation at 18 global sites.<\/span><br \/>\n<span>\u2022 Included 597 videos of confirmed cardiac amyloidosis and 2,122 controls.<\/span><br \/>\n<span>\u2022 Used apical 4-chamber echocardiographic views.<\/span><br \/>\n<span>7. Performance Metrics<\/span><br \/>\n<span>\u2022 AUROC: 0.93<\/span><br \/>\n<span>\u2022 Sensitivity: 85%<\/span><br \/>\n<span>\u2022 Specificity: 93%<\/span><br \/>\n<span>\u2022 Outperformed other markers like transthyretin (AUROC: 0.73) and wall thickness (AUROC: 0.80).<\/span><br \/>\n<span>8. Clinical Application<\/span><br \/>\n<span>\u2022 Echo labs can upload echo clips to a secure platform and receive automated AI analysis: \u201clikely,\u201d \u201cunlikely,\u201d or \u201cindeterminate.\u201d<\/span><br \/>\n<span>9. Treatment Implications<\/span><br \/>\n<span>\u2022 Early detection enables initiation of therapies before irreversible damage.<\/span><br \/>\n<span>\u2022 FDA-approved medications:<\/span><br \/>\n<span>\u2022 Tafamidis (Vyndamax)<\/span><br \/>\n<span>\u2022 Acoramidis (Attruby)<\/span><br \/>\n<span>\u2022 Vutrisiran (Amvuttra)<\/span><br \/>\n<span>\u2022 These drugs slow disease progression but do not reverse existing damage.<\/span><\/p>\n<p><span>Link:\u00a0<\/span><a href=\"http:\/\/www.cardiovascularbusiness.com\/news\/ai-can-spot-lurking-heart-condition\" target=\"_blank\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/www.cardiovascularbusiness.com\/news\/ai-can-spot-lurking-heart-condition&amp;source=gmail&amp;ust=1753173145315000&amp;usg=AOvVaw2FbUS-6LH4dlGOb8wm1sAm\" rel=\"noopener\">http:\/\/www.<wbr \/>cardiovascularbusiness.com\/<wbr \/>news\/ai-can-spot-lurking-<wbr \/>heart-condition<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>AI Can Detect Cardiac Amyloidosis from Echo Videos Source: European Heart Journal | July 17, 2025 1. Overview of the Condition \u2022 Cardiac amyloidosis occurs when misfolded proteins deposit in the heart, leading to thickened walls and impaired function. \u2022 It mimics hypertensive heart disease and aortic stenosis, making diagnosis difficult, especially in early stages. [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8030","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=8030"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8030\/revisions"}],"predecessor-version":[{"id":8031,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8030\/revisions\/8031"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=8030"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=8030"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=8030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}