{"id":8381,"date":"2025-08-17T21:19:56","date_gmt":"2025-08-17T18:19:56","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=8381"},"modified":"2025-08-17T21:19:56","modified_gmt":"2025-08-17T18:19:56","slug":"coated-balloon-treatment-for-complex-coronary-stent-restenosis","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/coated-balloon-treatment-for-complex-coronary-stent-restenosis\/","title":{"rendered":"Coated Balloon Treatment for Complex Coronary Stent Restenosis"},"content":{"rendered":"<div>Coated Balloon Treatment for Complex Coronary Stent Restenosis<\/div>\n<div><\/div>\n<div>Source: Medscape Medical News \u2013 Journal of the American College of Cardiology<\/div>\n<div>Date: August 11, 2025<\/div>\n<div><\/div>\n<div>1. Study Background<\/div>\n<div><span> \u2022 In-stent restenosis (ISR) remains a difficult clinical problem after PCI.<\/span><\/div>\n<div><span> \u2022 Two main types exist:<\/span><\/div>\n<div><span> \u2022 Single-layer ISR = restenosis within one stent.<\/span><\/div>\n<div><span> \u2022 Multilayer ISR = restenosis in segments treated with multiple overlapping stents, which makes treatment more complex and prognosis poorer.<\/span><\/div>\n<div><span> \u2022 Researchers evaluated whether paclitaxel-coated balloons could improve outcomes compared with uncoated balloons, especially in multilayer ISR.<\/span><\/div>\n<div>2. Methodology<\/div>\n<div><span> \u2022 600 patients with ISR randomized (2:1) at 40 US sites.<\/span><\/div>\n<div><span> \u2022 Paclitaxel-coated balloon vs uncoated balloon.<\/span><\/div>\n<div><span> \u2022 44% had multilayer ISR.<\/span><\/div>\n<div><span> \u2022 Primary endpoint: Target lesion failure (TLF) at 1 year (death, MI, or repeat revascularization).<\/span><\/div>\n<div>3. Key Results<\/div>\n<div><span> \u2022 Multilayer ISR:<\/span><\/div>\n<div><span> \u2022 TLF: 23.8% (coated) vs 40% (uncoated) \u2192 HR 0.55; P = .01.<\/span><\/div>\n<div><span> \u2022 Revascularization: 17.4% vs 37.8%; P = .0003.<\/span><\/div>\n<div><span> \u2022 MI: 5.9% vs 17.2%; P = .005.<\/span><\/div>\n<div><span> \u2022 Stent thrombosis: 0 vs 6 cases.<\/span><\/div>\n<div><span> \u2022 Overall: Multilayer ISR had worse outcomes than single-layer ISR (29% vs 15.7% TLF).<\/span><\/div>\n<div>4. Clinical Implications<\/div>\n<div><span> \u2022 Paclitaxel-coated balloons reduce complications in multilayer ISR compared with uncoated balloons.<\/span><\/div>\n<div><span> \u2022 Still, long-term prognosis remains poor, stressing the need for:<\/span><\/div>\n<div><span> \u2022 Lifetime management strategies in ISR patients.<\/span><\/div>\n<div><span> \u2022 Optimal first strategy at the initial ISR occurrence.<\/span><\/div>\n<div><span> \u2022 Editorial highlights coated balloons as a valuable option in high-risk multilayer ISR patients.<\/span><\/div>\n<div><\/div>\n<div>Takeaway:<\/div>\n<div>Paclitaxel-coated balloons significantly lower restenosis-related complications in complex multilayer ISR, offering an effective treatment alternative, though challenges in overall prognosis remain.<\/div>\n<div><\/div>\n<div><a href=\"https:\/\/click.mail.medscape.com\/?qs=56e7bf83208ccef814f6bdeb96ed8d1845c4ce78dc9a78d2a0ac591b333fea075fd4fcbcdc6603b15c6055ef26d0e27f69368c3fd55b416c9e32b8867b1886bb\">https:\/\/click.mail.medscape.com\/?qs=56e7bf83208ccef814f6bdeb96ed8d1845c4ce78dc9a78d2a0ac591b333fea075fd4fcbcdc6603b15c6055ef26d0e27f69368c3fd55b416c9e32b8867b1886bb<\/a><\/div>\n<div><\/div>\n<div><a href=\"https:\/\/click.mail.medscape.com\/?qs=56e7bf83208ccef814f6bdeb96ed8d1845c4ce78dc9a78d2a0ac591b333fea075fd4fcbcdc6603b15c6055ef26d0e27f69368c3fd55b416c9e32b8867b1886bb\">https:\/\/click.mail.medscape.com\/?qs=56e7bf83208ccef814f6bdeb96ed8d1845c4ce78dc9a78d2a0ac591b333fea075fd4fcbcdc6603b15c6055ef26d0e27f69368c3fd55b416c9e32b8867b1886bb<\/a><\/div>\n<div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Coated Balloon Treatment for Complex Coronary Stent Restenosis Source: Medscape Medical News \u2013 Journal of the American College of Cardiology Date: August 11, 2025 1. Study Background \u2022 In-stent restenosis (ISR) remains a difficult clinical problem after PCI. \u2022 Two main types exist: \u2022 Single-layer ISR = restenosis within one stent. \u2022 Multilayer ISR = [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8381","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8381","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=8381"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8381\/revisions"}],"predecessor-version":[{"id":8382,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8381\/revisions\/8382"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=8381"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=8381"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=8381"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}