{"id":8454,"date":"2025-08-27T11:17:28","date_gmt":"2025-08-27T08:17:28","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=8454"},"modified":"2025-08-27T11:17:28","modified_gmt":"2025-08-27T08:17:28","slug":"driving-progress-in-cardiology-exploring-the-role-of-fxi-in-acute-coronary-syndromes-beyond","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/driving-progress-in-cardiology-exploring-the-role-of-fxi-in-acute-coronary-syndromes-beyond\/","title":{"rendered":"Driving Progress in Cardiology: Exploring the Role of FXI in Acute Coronary Syndromes &#038; Beyond"},"content":{"rendered":"<div>Driving Progress in Cardiology: Exploring the Role of FXI in Acute Coronary Syndromes &amp; Beyond<\/div>\n<div><\/div>\n<div>Source: SCAI 2025 Educational Program<\/div>\n<div>(Driving Progress in Cardiology \u2013 FXI in ACS &amp; Beyond )<\/div>\n<div><\/div>\n<div>FXI inhibitors = Factor XI \/ Factor XIa inhibitors in the coagulation cascade (target the intrinsic pathway to reduce thrombosis with lower bleeding risk).<\/div>\n<div><span> \u2022 FXI inhibition reduces clotting with less bleeding.<\/span><\/div>\n<div><span> \u2022 Promising in ACS as an add-on to antiplatelets.<\/span><\/div>\n<div><span> \u2022 Potential role also in stroke, AF, and VTE.<\/span><\/div>\n<div><\/div>\n<div>Summary :<\/div>\n<div><span> \u2022 Asundexian: Studied in PACIFIC trials (post-MI, AF, stroke).<\/span><\/div>\n<div><span> \u2022 Milvexian: Phase 2 (AXIOMATIC-SSP) and Phase 3 LIBREXIA program (stroke, ACS, AF).<\/span><\/div>\n<div><span> \u2022 Abelacimab: AZALEA-TIMI 71 (AF), VTE prevention post-arthroplasty.<\/span><\/div>\n<div><span> \u2022 Osocimab: Early safety trial in renal disease.<\/span><\/div>\n<div><\/div>\n<div><a href=\"https:\/\/luxsci.com\/1_ZFVhxHy7PZMIgloJ2_c_\/email-link\/194431\/2894\/take-me?v1=7F43C6C9C8906DB358C4B1EA3A1AE4155B6E9D50&amp;n1=1756120219&amp;to=https:\/\/reachmd.com\/segment\/32980\/%3fautoplay%3d1%26utm_source%3d30%26utm_medium%3d20%26utm_campaign%3d1332651%26utm_brand%3d1%26rmd_token%3d3d2c7c3664c7d4a000a58e423329d083ba60d5e04e11ef455046190fbddc2a72%26utm_segment%3d%26campaign%3dWNLMKT\">https:\/\/luxsci.com\/1_ZFVhxHy7PZMIgloJ2_c_\/email-link\/194431\/2894\/take-me?v1=7F43C6C9C8906DB358C4B1EA3A1AE4155B6E9D50&amp;n1=1756120219&amp;to=https:\/\/reachmd.com\/segment\/32980\/%3fautoplay%3d1%26utm_source%3d30%26utm_medium%3d20%26utm_campaign%3d1332651%26utm_brand%3d1%26rmd_token%3d3d2c7c3664c7d4a000a58e423329d083ba60d5e04e11ef455046190fbddc2a72%26utm_segment%3d%26campaign%3dWNLMKT<\/a><\/div>\n<div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Driving Progress in Cardiology: Exploring the Role of FXI in Acute Coronary Syndromes &amp; Beyond Source: SCAI 2025 Educational Program (Driving Progress in Cardiology \u2013 FXI in ACS &amp; Beyond ) FXI inhibitors = Factor XI \/ Factor XIa inhibitors in the coagulation cascade (target the intrinsic pathway to reduce thrombosis with lower bleeding risk). [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8454","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8454","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=8454"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8454\/revisions"}],"predecessor-version":[{"id":8456,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8454\/revisions\/8456"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=8454"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=8454"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=8454"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}