{"id":8482,"date":"2025-09-02T12:25:07","date_gmt":"2025-09-02T09:25:07","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=8482"},"modified":"2025-09-02T12:25:07","modified_gmt":"2025-09-02T09:25:07","slug":"beta-blockers-after-mi-without-reduced-ejection-fraction","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/beta-blockers-after-mi-without-reduced-ejection-fraction\/","title":{"rendered":"Beta-Blockers after MI without Reduced Ejection Fraction"},"content":{"rendered":"<div>Beta-Blockers after MI without Reduced Ejection Fraction<\/div>\n<div><\/div>\n<div>NEJM \u2013 August 30, 2025<\/div>\n<div><\/div>\n<div><span> 1. Background<\/span><\/div>\n<div><span> \u2022 Guidelines recommend beta-blockers after MI, but evidence comes from older trials (before modern reperfusion, stents, and contemporary drugs).<\/span><\/div>\n<div><span> \u2022 Uncertainty remains for patients with preserved EF (&gt;40%).<\/span><\/div>\n<div><span> 2. Methods<\/span><\/div>\n<div><span> \u2022 Open-label, randomized trial in Spain &amp; Italy.<\/span><\/div>\n<div><span> \u2022 8,438 patients with acute MI (STEMI &amp; NSTEMI), EF &gt;40%.<\/span><\/div>\n<div><span> \u2022 Randomized to beta-blocker therapy vs. no beta-blocker.<\/span><\/div>\n<div><span> \u2022 Primary outcome = composite of all-cause death, reinfarction, or HF hospitalization.<\/span><\/div>\n<div><span> \u2022 Median follow-up: 3.7 years.<\/span><\/div>\n<div><span> 3. Results<\/span><\/div>\n<div><span> \u2022 Primary outcome: No difference (HR 1.04; CI 0.89\u20131.22; P=0.63).<\/span><\/div>\n<div><span> \u2022 Death: 11.2 vs. 10.5 events\/1000 pt-yrs (HR 1.06).<\/span><\/div>\n<div><span> \u2022 Reinfarction: 10.2 vs. 10.1 events\/1000 pt-yrs (HR 1.01).<\/span><\/div>\n<div><span> \u2022 HF hospitalization: 2.7 vs. 3.0 events\/1000 pt-yrs (HR 0.89).<\/span><\/div>\n<div><span> \u2022 Safety: No major differences.<\/span><\/div>\n<div><span> 4. Conclusion<\/span><\/div>\n<div><span> \u2022 In post-MI patients with EF &gt;40% receiving modern invasive &amp; pharmacologic care, beta-blockers did not reduce mortality, reinfarction, or HF hospitalization.<\/span><\/div>\n<div><span> \u2022 Suggests limited benefit for routine use in this subgroup.<\/span><\/div>\n<div><\/div>\n<div><a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2504735\">http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2504735<\/a><\/div>\n<div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Beta-Blockers after MI without Reduced Ejection Fraction NEJM \u2013 August 30, 2025 1. Background \u2022 Guidelines recommend beta-blockers after MI, but evidence comes from older trials (before modern reperfusion, stents, and contemporary drugs). \u2022 Uncertainty remains for patients with preserved EF (&gt;40%). 2. Methods \u2022 Open-label, randomized trial in Spain &amp; Italy. \u2022 8,438 patients [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8482","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=8482"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8482\/revisions"}],"predecessor-version":[{"id":8483,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8482\/revisions\/8483"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=8482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=8482"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=8482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}