{"id":8586,"date":"2025-09-13T14:51:21","date_gmt":"2025-09-13T11:51:21","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=8586"},"modified":"2025-09-13T14:51:21","modified_gmt":"2025-09-13T11:51:21","slug":"help-mi-swedeheart-trial-h-pylori-screening-in-mi","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/help-mi-swedeheart-trial-h-pylori-screening-in-mi\/","title":{"rendered":"HELP-MI SWEDEHEART Trial \u2013 H. pylori Screening in MI"},"content":{"rendered":"<div>HELP-MI SWEDEHEART Trial \u2013 H. pylori Screening in MI<\/div>\n<div><\/div>\n<div>Source: Brian Owens, JAMA \/ ESC Congress 2025, Sept 5, 2025<\/div>\n<div><span> 1. Background<\/span><\/div>\n<div><span> \u2022 Upper GI bleeding is a common complication after MI.<\/span><\/div>\n<div><span> \u2022 Linked to H. pylori infection and worsened by antithrombotic therapy.<\/span><\/div>\n<div><span> 2. Trial Design<\/span><\/div>\n<div><span> \u2022 Cluster-randomized crossover, 18,000+ MI patients at 35 Swedish hospitals.<\/span><\/div>\n<div><span> \u2022 Screening with urea breath test.<\/span><\/div>\n<div><span> \u2022 Found: 10% reduction in GI bleeding risk, not statistically significant.<\/span><\/div>\n<div><span> 3. Limitations<\/span><\/div>\n<div><span> \u2022 Only 70% of patients actually screened.<\/span><\/div>\n<div><span> \u2022 H. pylori prevalence low (~23%).<\/span><\/div>\n<div><span> \u2022 25% already on PPIs in both arms.<\/span><\/div>\n<div><span> 4. High-Risk Subgroups<\/span><\/div>\n<div><span> \u2022 Patients with anemia or kidney failure saw ~50% relative risk reduction.<\/span><\/div>\n<div><span> \u2022 Numbers too small for statistical confirmation.<\/span><\/div>\n<div><span> 5. Interpretation<\/span><\/div>\n<div><span> \u2022 Overall neutral, but clinically positive trends across subgroups.<\/span><\/div>\n<div><span> \u2022 Experts suggest screening may benefit high-risk patients.<\/span><\/div>\n<div><span> 6. Implications<\/span><\/div>\n<div><span> \u2022 Urea breath test + eradication therapy are simple, safe, inexpensive.<\/span><\/div>\n<div><span> \u2022 Could be recommended in high-risk MI patients to reduce bleeding.<\/span><\/div>\n<div><span> \u2022 Guideline committees will decide on adoption.<\/span><\/div>\n<div><\/div>\n<div>Take-home line:<\/div>\n<div>\u201cRoutine H. pylori screening after MI shows no overall benefit, but may cut bleeding risk significantly in high-risk patients (e.g., anemia, kidney failure).\u201d<\/div>\n<div><\/div>\n<div><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40887995\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/40887995\/<\/a><\/div>\n<div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>HELP-MI SWEDEHEART Trial \u2013 H. pylori Screening in MI Source: Brian Owens, JAMA \/ ESC Congress 2025, Sept 5, 2025 1. Background \u2022 Upper GI bleeding is a common complication after MI. \u2022 Linked to H. pylori infection and worsened by antithrombotic therapy. 2. Trial Design \u2022 Cluster-randomized crossover, 18,000+ MI patients at 35 Swedish [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8586","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8586","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=8586"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8586\/revisions"}],"predecessor-version":[{"id":8587,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8586\/revisions\/8587"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=8586"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=8586"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=8586"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}