{"id":8666,"date":"2025-09-18T00:37:45","date_gmt":"2025-09-17T21:37:45","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=8666"},"modified":"2025-09-18T00:37:45","modified_gmt":"2025-09-17T21:37:45","slug":"beta-blockers-after-mi-in-mildly-reduced-ef","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/beta-blockers-after-mi-in-mildly-reduced-ef\/","title":{"rendered":"Beta-Blockers After MI in Mildly Reduced EF"},"content":{"rendered":"<div>Beta-Blockers After MI in Mildly Reduced EF<\/div>\n<div><\/div>\n<div>Source: ESC Congress 2025 \u2013 The Lancet<\/div>\n<div>Date: 30 August 2025<\/div>\n<div><\/div>\n<div>1.<span> <\/span>Background<\/div>\n<div><\/div>\n<div><span> \u2022 Post-MI patients with LVEF 40\u201349% (mildly reduced) and no HF = large but understudied group.<\/span><\/div>\n<div><\/div>\n<div><span> \u2022 Who Was Studied?:<\/span><\/div>\n<div><span> \u2022 Post-MI patients with LVEF 40\u201349% (mildly reduced) and no HF.<\/span><\/div>\n<div><span> \u2022 Data pooled from 4 trials: REBOOT, BETAMI, DANBLOCK, CAPITAL-RCT.<\/span><\/div>\n<div><span> \u2022 Total: 1,885 patients.<\/span><\/div>\n<div>2.<span> <\/span>Main Finding<\/div>\n<div><span> \u2022 Primary outcome (death, new MI, or HF):<\/span><\/div>\n<div><span> \u2022 10.7% with beta-blockers vs 14.4% without.<\/span><\/div>\n<div><span> \u2022 25% lower risk (HR 0.75; p=0.031).<\/span><\/div>\n<div>3.<span> <\/span>Individual Outcomes<\/div>\n<div><span> \u2022 Death: 5.9% vs 7.7% (HR 0.78).<\/span><\/div>\n<div><span> \u2022 New MI: 3.9% vs 5.2% (HR 0.77).<\/span><\/div>\n<div><span> \u2022 Heart failure: 3.0% vs 4.4% (HR 0.71).<\/span><\/div>\n<div><span> \u2022 Cardiac death: 1.8% vs 3.3% (HR 0.55).<\/span><\/div>\n<div>4.<span> <\/span>Consistency<\/div>\n<div><span> \u2022 Results were similar across all 4 trials and countries.<\/span><\/div>\n<div>5.<span> <\/span>Conclusion<\/div>\n<div><span> \u2022 Beta-blockers improve outcomes after MI in patients with mildly reduced EF (40\u201349%).<\/span><\/div>\n<div><span> \u2022 Extends benefit beyond reduced EF (&lt;40%).<\/span><\/div>\n<div><span> \u2022 Next step: study in patients with preserved EF (&gt;50%).<\/span><\/div>\n<div><\/div>\n<div><a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2825%2901592-2\/abstract?utm_source=chatgpt.com\">https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2825%2901592-2\/abstract?utm_source=chatgpt.com<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Beta-Blockers After MI in Mildly Reduced EF Source: ESC Congress 2025 \u2013 The Lancet Date: 30 August 2025 1. Background \u2022 Post-MI patients with LVEF 40\u201349% (mildly reduced) and no HF = large but understudied group. \u2022 Who Was Studied?: \u2022 Post-MI patients with LVEF 40\u201349% (mildly reduced) and no HF. \u2022 Data pooled from [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8666","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8666","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=8666"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8666\/revisions"}],"predecessor-version":[{"id":8667,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8666\/revisions\/8667"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=8666"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=8666"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=8666"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}