{"id":8707,"date":"2025-09-20T19:44:45","date_gmt":"2025-09-20T16:44:45","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=8707"},"modified":"2025-09-20T19:44:45","modified_gmt":"2025-09-20T16:44:45","slug":"esc-2025-drug-coated-devices-in-pad","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/esc-2025-drug-coated-devices-in-pad\/","title":{"rendered":"ESC 2025 \u2013 Drug-Coated Devices in PAD"},"content":{"rendered":"<div>ESC 2025 \u2013 Drug-Coated Devices in PAD<\/div>\n<div><\/div>\n<div>Source: Medscape Medical News, Sept 19, 2025 \u2013 ESC Congress, Madrid<\/div>\n<div><span> 1. Background:<\/span><\/div>\n<div><span> \u2022 Drug-coated stents\/balloons (mostly paclitaxel) tested vs. uncoated devices in PAD.<\/span><\/div>\n<div><span> \u2022 Two RCTs: SWEDEPAD 1 (chronic limb-threatening ischemia, n=2355) and SWEDEPAD 2 (intermittent claudication, n=1155).<\/span><\/div>\n<div><span> 2. Key Results \u2013 SWEDEPAD 1:<\/span><\/div>\n<div><span> \u2022 No difference in major amputations (primary endpoint).<\/span><\/div>\n<div><span> \u2022 Slight reduction in reinterventions at 1 year with coated devices, but effect faded.<\/span><\/div>\n<div><span> \u2022 No difference in mortality.<\/span><\/div>\n<div><span> 3. Key Results \u2013 SWEDEPAD 2:<\/span><\/div>\n<div><span> \u2022 No improvement in quality of life (primary endpoint).<\/span><\/div>\n<div><span> \u2022 No difference in reinterventions or long-term mortality.<\/span><\/div>\n<div><span> \u2022 At 5 years: 47% higher mortality with drug-coated devices (signal of concern).<\/span><\/div>\n<div><span> 4. Controversy:<\/span><\/div>\n<div><span> \u2022 Mortality concerns with paclitaxel devices first raised in 2018; large registries (300,000 pts) later suggested safety.<\/span><\/div>\n<div><\/div>\n<div><a href=\"https:\/\/click.mail.medscape.com\/?qs=c9cb83c52070cc98cd76c69f57d8ee3adbd60afd003d97d4e1643ce195ab51fe3f5b89bbc058ff60b4c61f6262f611dedcdb1643ca27ef3ca9de7e97c48b65b8\">https:\/\/click.mail.medscape.com\/?qs=c9cb83c52070cc98cd76c69f57d8ee3adbd60afd003d97d4e1643ce195ab51fe3f5b89bbc058ff60b4c61f6262f611dedcdb1643ca27ef3ca9de7e97c48b65b8<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>ESC 2025 \u2013 Drug-Coated Devices in PAD Source: Medscape Medical News, Sept 19, 2025 \u2013 ESC Congress, Madrid 1. Background: \u2022 Drug-coated stents\/balloons (mostly paclitaxel) tested vs. uncoated devices in PAD. \u2022 Two RCTs: SWEDEPAD 1 (chronic limb-threatening ischemia, n=2355) and SWEDEPAD 2 (intermittent claudication, n=1155). 2. Key Results \u2013 SWEDEPAD 1: \u2022 No difference [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8707","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8707","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=8707"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8707\/revisions"}],"predecessor-version":[{"id":8708,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8707\/revisions\/8708"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=8707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=8707"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=8707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}