{"id":8849,"date":"2025-10-06T00:27:24","date_gmt":"2025-10-05T21:27:24","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=8849"},"modified":"2025-10-06T00:28:06","modified_gmt":"2025-10-05T21:28:06","slug":"aspirin-and-cancer-prevention-source-medscape-september-26-2025","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/aspirin-and-cancer-prevention-source-medscape-september-26-2025\/","title":{"rendered":"Aspirin and Cancer Prevention"},"content":{"rendered":"<div>Aspirin and Cancer Prevention<\/div>\n<div><\/div>\n<div>Source: Medscape , September 26, 2025.<\/div>\n<div><\/div>\n<div><span> 1. Background<\/span><\/div>\n<div><span> \u2022 Aspirin is well-known as an antiplatelet drug for cardiovascular disease but also shows anticancer effects, especially in preventing colorectal polyps and adenomas.<\/span><\/div>\n<div><span> \u2022 Mechanism: COX inhibition \u2192 \u2193 prostaglandins \u2192 \u2193 polyp formation; also promotes apoptosis. Similar effects seen with other NSAIDs.<\/span><\/div>\n<div><span> 2. Evidence<\/span><\/div>\n<div><span> \u2022 Meta-analysis (4 RCTs) = Randomized Controlled Trials : 6.7% absolute risk reduction in adenomas.<\/span><\/div>\n<div><span> \u2022 Major trials (Physicians\u2019 Health, Women\u2019s Health, ASCEND, ARRIVE)<\/span><\/div>\n<div><span> \u2022 Long follow-up required: benefit seen after 10\u201320 years.<\/span><\/div>\n<div><span> \u2022 2012 Lancet meta-analysis: \u2193 colon cancer by 3.13\/1000 people\/year.<\/span><\/div>\n<div><span> \u2022 Long-term mortality reduction (20 years): absolute risk reduction ~1.76%.<\/span><\/div>\n<div><span> 3. Limitations<\/span><\/div>\n<div><span> \u2022 Bleeding risk starts immediately (GI bleeds, intracranial hemorrhage, bruising).<\/span><\/div>\n<div><span> \u2022 Benefit requires \u226510 years of continuous aspirin use.<\/span><\/div>\n<div><span> \u2022 Cancer screening (e.g., colonoscopy) more effective and cost-efficient than aspirin prophylaxis.<\/span><\/div>\n<div><span> 4. Conclusion<\/span><\/div>\n<div><span> \u2022 Aspirin does reduce colorectal adenomas and long-term colon cancer risk.<\/span><\/div>\n<div><span> \u2022 Not recommended for primary prevention of cancer; screening remains superior.<\/span><\/div>\n<div><\/div>\n<div><a href=\"https:\/\/click.mail.medscape.com\/?qs=81b7b1181eac089721fb6a6268fd36eb86c320b8cb7f6104b1f5fd6a257d36426e6c5eaa24c7a1b1ffe1793c5c6ec932a516f144eccbeb58ff590fa3d8215440\">https:\/\/click.mail.medscape.com\/?qs=81b7b1181eac089721fb6a6268fd36eb86c320b8cb7f6104b1f5fd6a257d36426e6c5eaa24c7a1b1ffe1793c5c6ec932a516f144eccbeb58ff590fa3d8215440<\/a><\/div>\n<div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Aspirin and Cancer Prevention Source: Medscape , September 26, 2025. 1. Background \u2022 Aspirin is well-known as an antiplatelet drug for cardiovascular disease but also shows anticancer effects, especially in preventing colorectal polyps and adenomas. \u2022 Mechanism: COX inhibition \u2192 \u2193 prostaglandins \u2192 \u2193 polyp formation; also promotes apoptosis. Similar effects seen with other NSAIDs. [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8849","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8849","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=8849"}],"version-history":[{"count":2,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8849\/revisions"}],"predecessor-version":[{"id":8851,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/8849\/revisions\/8851"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=8849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=8849"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=8849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}