{"id":9038,"date":"2025-10-27T20:38:28","date_gmt":"2025-10-27T17:38:28","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=9038"},"modified":"2025-10-27T20:38:28","modified_gmt":"2025-10-27T17:38:28","slug":"a-new-era-in-pci-sirolimus-eluting-balloon-could-change-how-we-treat-coronary-disease-insights-from-tct-2025","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/a-new-era-in-pci-sirolimus-eluting-balloon-could-change-how-we-treat-coronary-disease-insights-from-tct-2025\/","title":{"rendered":"A New Era in PCI: Sirolimus-Eluting Balloon Could Change How We Treat Coronary Disease \u2014 Insights from TCT 2025"},"content":{"rendered":"<div>A New Era in PCI: Sirolimus-Eluting Balloon Could Change How We Treat Coronary Disease \u2014 Insights from TCT 2025<\/div>\n<div><\/div>\n<div>Source: TCT 2025 \u2013 San Francisco, October 25\u201328, 2025<\/div>\n<div>(Recent trials presented at TCT 2025 (Oct 25\u201328, San Francisco) show that sirolimus-eluting balloons may deliver results comparable to stents\u2014while eliminating the need to leave metal behind, signaling a potential shift toward a fully restorative, stent-free PCI strategy).<\/div>\n<div><\/div>\n<div>Highlights from TCT 2025:<\/div>\n<div><span> 1. SELUTION DeNovo Trial (de novo = new lesions)<\/span><\/div>\n<div><span> \u2022 Patients: 3,323 with newly diagnosed coronary artery disease.<\/span><\/div>\n<div><span> \u2022 Results: Target Vessel Failure (TVF) 5.3 % vs 4.4 % in DES \u2192 non-inferior.<\/span><\/div>\n<div><span> \u2022 \u2248 80 % avoided stent implantation.<\/span><\/div>\n<div><span> \u2022 Meaning: Comparable efficacy with fewer implants \u2192 possible paradigm shift in PCI.<\/span><\/div>\n<div><span> 2. SELUTION4ISR Trial<\/span><\/div>\n<div><span> \u2022 Patients: 418 with in-stent restenosis (ISR).<\/span><\/div>\n<div><span> \u2022 Comparator: Standard care (\u2248 80 % DES + 20 % balloon angioplasty).<\/span><\/div>\n<div><span> \u2022 Target Lesion Failure (TLF): 15.2 % vs 13.5 % \u2192 non-inferior.<\/span><\/div>\n<div><span> \u2022 Safety: No significant differences in cardiac death, MI, or repeat revascularization.<\/span><\/div>\n<div><span> \u2022 Implication: First sirolimus DEB to match DES for ISR without adding metal layers.<\/span><\/div>\n<div><span> 3. Expert Perspective<\/span><\/div>\n<div><span> \u2022 Dr. Spaulding: \u201cA journey toward stent-free PCI.\u201d<\/span><\/div>\n<div><span> \u2022 Dr. Cutlip: Confirmed non-inferiority in ISR management.<\/span><\/div>\n<div><span> \u2022 Dr. Sethi: Predicted DEB therapy could become future standard of care.<\/span><\/div>\n<div><\/div>\n<div>Key Takeaway:<\/div>\n<div>The sirolimus-eluting balloon shows comparable efficacy, safety, and durability to DES while preserving vessel physiology \u2014 a step that may redefine how we treat coronary disease in the years ahead.<\/div>\n<div><\/div>\n<div><a href=\"https:\/\/www.tctconference.com\">https:\/\/www.tctconference.com<\/a><\/div>\n<div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>A New Era in PCI: Sirolimus-Eluting Balloon Could Change How We Treat Coronary Disease \u2014 Insights from TCT 2025 Source: TCT 2025 \u2013 San Francisco, October 25\u201328, 2025 (Recent trials presented at TCT 2025 (Oct 25\u201328, San Francisco) show that sirolimus-eluting balloons may deliver results comparable to stents\u2014while eliminating the need to leave metal behind, [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9038","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9038","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=9038"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9038\/revisions"}],"predecessor-version":[{"id":9039,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9038\/revisions\/9039"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=9038"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=9038"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=9038"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}