{"id":9242,"date":"2025-11-22T13:51:10","date_gmt":"2025-11-22T10:51:10","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=9242"},"modified":"2025-11-22T13:51:10","modified_gmt":"2025-11-22T10:51:10","slug":"lower-ldl-cholesterol-cuts-stroke-risk-by-25","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/lower-ldl-cholesterol-cuts-stroke-risk-by-25\/","title":{"rendered":"Lower LDL Cholesterol Cuts Stroke Risk by 25%"},"content":{"rendered":"<div class=\"page\" title=\"Page 1\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p><span>Lower LDL Cholesterol Cuts Stroke Risk by 25%\\\\<\/span><\/p>\n<div class=\"page\" title=\"Page 2\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p><span>Lowering LDL Cholesterol Linked to 25% Lower Stroke Risk <\/span><\/p>\n<p><span>Source: Medscape Medical News \u2013 AHA Scientific Sessions 2025 (November 11, 2025) <\/span><\/p>\n<p><span>Keynotes: <\/span><\/p>\n<p><span>1) Achieving LDL &lt; 40 mg\/dL in patients with prior ischemic stroke significantly reduces:<br \/>\n\u2022 31% <\/span><span>\u2193 <\/span><span>MACE<br \/>\n\u2022 27% <\/span><span>\u2193 <\/span><span>all strokes <\/span><\/p>\n<p><span>\u2022 25% <\/span><span>\u2193 <\/span><span>ischemic stroke<br \/>\n\u2022 No increase in hemorrhagic stroke risk. <\/span><\/p>\n<p><span>Study Details <\/span><\/p>\n<p><span>\u2022 Data from 5291 patients (FOURIER + FOURIER-OLE).<br \/>\n\u2022 Follow-up: 7\u20138 years.<br \/>\n\u2022 Benefit increased stepwise as LDL decreased (\u201cthe lower, the better\u201d). \u2022 Even &lt;20 mg\/dL showed no safety signal. <\/span><\/p>\n<p><span>Clinical Meaning <\/span><\/p>\n<p><span>\u2022 Extremely low LDL appears safe despite concerns about hemorrhagic stroke. \u2022 Supports aggressive LDL targets for stroke survivors.<br \/>\n\u2022 May influence AHA\/ACC 2026 guideline update. <\/span><\/p>\n<p><span>Background Context <\/span><\/p>\n<p><span>\u2022 US guideline threshold: &lt;70 mg\/dL (AHA\/ACC 2018).<br \/>\n\u2022 ESC\/EAS 2019 recommends &lt;55 mg\/dL for very high-risk patients. \u2022 New analysis suggests &lt;40 mg\/dL may be ideal. <\/span><\/p>\n<p><span>Expert Opinions <\/span><\/p>\n<p><span>\u2022 \u201cNo floor effect \u2014 lower LDL consistently improves outcomes.\u201d \u2022 External experts confirm strong safety and benefit data. <\/span><\/p>\n<p><span>Conclusion <\/span><\/p>\n<p><span>Very intensive LDL lowering (&lt;40 mg\/dL) in ischemic stroke patients: <\/span><span>\u2192 <\/span><span>reduces recurrent stroke &amp; cardiovascular events<br \/>\n<\/span><span>\u2192 <\/span><span>does not increase hemorrhagic stroke<br \/>\n<\/span><span>\u2192 <\/span><span>likely practice-changing in 2026 <\/span><\/p>\n<p><span>Link:<\/span><\/p>\n<div class=\"page\" title=\"Page 3\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p><span>https:\/\/click.mail.medscape.com\/?qs=4a4e031c51946eac1d4e6edf8c51cf86973252fa 0386295197901da96911161482e6c1a293db3b87dba20e04a946797349e5171934ca adfd7593d954ab169c7e <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Lower LDL Cholesterol Cuts Stroke Risk by 25%\\\\ Lowering LDL Cholesterol Linked to 25% Lower Stroke Risk Source: Medscape Medical News \u2013 AHA Scientific Sessions 2025 (November 11, 2025) Keynotes: 1) Achieving LDL &lt; 40 mg\/dL in patients with prior ischemic stroke significantly reduces: \u2022 31% \u2193 MACE \u2022 27% \u2193 all strokes \u2022 25% [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9242","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9242","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=9242"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9242\/revisions"}],"predecessor-version":[{"id":9243,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9242\/revisions\/9243"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=9242"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=9242"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=9242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}