{"id":9271,"date":"2025-11-22T14:22:28","date_gmt":"2025-11-22T11:22:28","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=9271"},"modified":"2025-11-22T14:22:28","modified_gmt":"2025-11-22T11:22:28","slug":"lowering-ldl-cholesterol-linked-to-25-lower-stroke-risk-2","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/lowering-ldl-cholesterol-linked-to-25-lower-stroke-risk-2\/","title":{"rendered":"Lowering LDL Cholesterol Linked to 25% Lower Stroke Risk"},"content":{"rendered":"<div>Lowering LDL Cholesterol Linked to 25% Lower Stroke Risk<\/div>\n<div><\/div>\n<div>Author: Deborah Brauser<\/div>\n<div>Source: Medscape Medical News \u2013 AHA Scientific Sessions 2025<\/div>\n<div>Date: November 11, 2025<\/div>\n<div><\/div>\n<div>Keynotes:<\/div>\n<div>1)\u00a0 \u00a0\u2022<span> <\/span>Achieving LDL &lt; 40 mg\/dL in patients with prior ischemic stroke significantly reduces:<\/div>\n<div><span> \u2022 31% \u2193 MACE<\/span><\/div>\n<div><span> \u2022 27% \u2193 all strokes<\/span><\/div>\n<div><span> \u2022 25% \u2193 ischemic stroke<\/span><\/div>\n<div><span> \u2022 No increase in hemorrhagic stroke risk.<\/span><\/div>\n<div><\/div>\n<div>2) Study Details<\/div>\n<div><span> \u2022 Data from 5291 patients (FOURIER + FOURIER-OLE).<\/span><\/div>\n<div><span> \u2022 Follow-up: 7\u20138 years.<\/span><\/div>\n<div><span> \u2022 Benefit increased stepwise as LDL decreased (\u201cthe lower, the better\u201d).<\/span><\/div>\n<div><span> \u2022 Even &lt;20 mg\/dL showed no safety signal.<\/span><\/div>\n<div><\/div>\n<div>3) Clinical Meaning<\/div>\n<div><span> \u2022 Extremely low LDL appears safe despite older concerns about hemorrhagic stroke.<\/span><\/div>\n<div><span> \u2022 Supports more aggressive LDL targets for stroke survivors.<\/span><\/div>\n<div><span> \u2022 May influence upcoming AHA\/ACC 2026 cholesterol guideline update.<\/span><\/div>\n<div><\/div>\n<div>4) Background Context<\/div>\n<div><span> \u2022 Current US guideline threshold: &lt;70 mg\/dL (AHA\/ACC 2018).<\/span><\/div>\n<div><span> \u2022 ESC\/EAS 2019 recommends &lt;55 mg\/dL for very high-risk patients.<\/span><\/div>\n<div><span> \u2022 The new analysis suggests even &lt;40 mg\/dL may be ideal.<\/span><\/div>\n<div><\/div>\n<div>5) Expert Opinions<\/div>\n<div><span> \u2022 Investigators: \u201cNo floor effect \u2014 lower LDL consistently improves outcomes.\u201d<\/span><\/div>\n<div><span> \u2022 External experts confirm results as strong evidence supporting safety and benefit.<\/span><\/div>\n<div><\/div>\n<div>6) Conclusion<\/div>\n<div><span> \u2022 Very intensive LDL lowering (&lt;40 mg\/dL) in ischemic stroke patients<\/span><\/div>\n<div>\u2192 reduces recurrent stroke &amp; cardiovascular events<\/div>\n<div>\u2192 no increase in hemorrhagic stroke<\/div>\n<div>\u2192 likely practice-changing in 2026<\/div>\n<div><\/div>\n<div><a href=\"https:\/\/click.mail.medscape.com\/?qs=4a4e031c51946eac1d4e6edf8c51cf86973252fa0386295197901da96911161482e6c1a293db3b87dba20e04a946797349e5171934caadfd7593d954ab169c7e\">https:\/\/click.mail.medscape.com\/?qs=4a4e031c51946eac1d4e6edf8c51cf86973252fa0386295197901da96911161482e6c1a293db3b87dba20e04a946797349e5171934caadfd7593d954ab169c7e<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Lowering LDL Cholesterol Linked to 25% Lower Stroke Risk Author: Deborah Brauser Source: Medscape Medical News \u2013 AHA Scientific Sessions 2025 Date: November 11, 2025 Keynotes: 1)\u00a0 \u00a0\u2022 Achieving LDL &lt; 40 mg\/dL in patients with prior ischemic stroke significantly reduces: \u2022 31% \u2193 MACE \u2022 27% \u2193 all strokes \u2022 25% \u2193 ischemic stroke [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9271","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9271","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=9271"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9271\/revisions"}],"predecessor-version":[{"id":9272,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9271\/revisions\/9272"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=9271"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=9271"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=9271"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}