{"id":9407,"date":"2025-12-21T21:47:28","date_gmt":"2025-12-21T18:47:28","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=9407"},"modified":"2025-12-21T21:47:28","modified_gmt":"2025-12-21T18:47:28","slug":"should-bp-be-lowered-in-isolated-diastolic-hypertension","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/should-bp-be-lowered-in-isolated-diastolic-hypertension\/","title":{"rendered":"Should BP Be Lowered in Isolated Diastolic Hypertension?\u00a0"},"content":{"rendered":"<div>Should BP Be Lowered in Isolated Diastolic Hypertension?<\/div>\n<div>Source (Secondary):<\/div>\n<div>Medscape , December 17, 2025<\/div>\n<div>Primary Source:<\/div>\n<div>European Heart Journal Dec\u2014 Key Points<\/div>\n<div><\/div>\n<div><span> \u2022 Large evidence base: Individual participant data meta-analysis of 51 randomized controlled trials including 358,325 adults.<\/span><\/div>\n<div><span> \u2022 Definition used: Isolated diastolic hypertension (IDH) = SBP &lt;130 mm Hg with DBP \u226580 mm Hg (alternative definition also tested).<\/span><\/div>\n<div><span> \u2022 Population: Only 4.4% had IDH, but outcomes were robust across subgroups.<\/span><\/div>\n<div><span> \u2022 Main finding:<\/span><\/div>\n<div><span> \u2022 A 5-mm Hg reduction in systolic BP was associated with an approximately 10% reduction in major cardiovascular events, both in patients with and without IDH.<\/span><\/div>\n<div><span> \u2022 Consistency across DBP levels:<\/span><\/div>\n<div><span> \u2022 Benefit of lowering systolic BP was similar across all diastolic BP ranges, even when baseline DBP was &lt;60 mm Hg.<\/span><\/div>\n<div><span> \u2022 No effect modification:<\/span><\/div>\n<div><span> \u2022 Benefits did not differ by age, prior cardiovascular disease, prior antihypertensive use, or BP measurement method.<\/span><\/div>\n<div><span> \u2022 Clinical implication:<\/span><\/div>\n<div><span> \u2022 Challenges the idea that IDH is a benign condition or should be excluded from BP-lowering treatment decisions.<\/span><\/div>\n<div><span> \u2022 Guideline impact:<\/span><\/div>\n<div><span> \u2022 Supports a more inclusive, risk-based approach to antihypertensive therapy rather than rigid BP phenotype definitions.<\/span><\/div>\n<div><span> \u2022 Caveat:<\/span><\/div>\n<div><span> \u2022 Dedicated randomized trials comparing tight vs less tight BP targets specifically in IDH are still needed.<\/span><\/div>\n<div><\/div>\n<div><a href=\"https:\/\/academic.oup.com\/eurheartj\/advance-article-pdf\/doi\/10.1093\/eurheartj\/ehaf962\/65852562\/ehaf962.pdf?utm_source=chatgpt.com\">https:\/\/academic.oup.com\/eurheartj\/advance-article-pdf\/doi\/10.1093\/eurheartj\/ehaf962\/65852562\/ehaf962.pdf?utm_source=chatgpt.com<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Should BP Be Lowered in Isolated Diastolic Hypertension? Source (Secondary): Medscape , December 17, 2025 Primary Source: European Heart Journal Dec\u2014 Key Points \u2022 Large evidence base: Individual participant data meta-analysis of 51 randomized controlled trials including 358,325 adults. \u2022 Definition used: Isolated diastolic hypertension (IDH) = SBP &lt;130 mm Hg with DBP \u226580 mm [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9407","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=9407"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9407\/revisions"}],"predecessor-version":[{"id":9408,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9407\/revisions\/9408"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=9407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=9407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=9407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}