{"id":9553,"date":"2026-02-21T19:45:32","date_gmt":"2026-02-21T16:45:32","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=9553"},"modified":"2026-02-21T19:45:32","modified_gmt":"2026-02-21T16:45:32","slug":"quadpill-at-quarter-dose-a-new-first-line-strategy-in-hypertension","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/quadpill-at-quarter-dose-a-new-first-line-strategy-in-hypertension\/","title":{"rendered":"Quadpill at Quarter Dose \u2013 A New First-Line Strategy in Hypertension"},"content":{"rendered":"<div>Quadpill at Quarter Dose \u2013 A New First-Line Strategy in Hypertension<\/div>\n<div><\/div>\n<div>Medscape Cardiology, February 13, 2026<\/div>\n<div><\/div>\n<div>QUARTET Trial -Published in The Lancet<\/div>\n<div><\/div>\n<div><span> \u2022 Ultra\u2013low-dose quadpill (\u00bc standard dose each: irbesartan 37.5 mg, amlodipine 1.25 mg, indapamide 0.625 mg, bisoprolol 2.5 mg) initiated from day one in mild\u2013moderate hypertension.<\/span><\/div>\n<div><span> \u2022 QUARTET trial showed superior BP reduction (~6\u20137 mmHg additional systolic lowering) versus standard-dose monotherapy, without increased serious adverse events.<\/span><\/div>\n<div><span> \u2022 Concept: early low-dose multidrug synergy may outperform stepwise escalation while maintaining tolerability<\/span><\/div>\n<div><\/div>\n<div><a href=\"https:\/\/www.medscape.com\/s\/viewarticle\/quadpill-strategy-gains-ground-hypertension-2026a10004lv\">https:\/\/www.medscape.com\/s\/viewarticle\/quadpill-strategy-gains-ground-hypertension-2026a10004lv<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Quadpill at Quarter Dose \u2013 A New First-Line Strategy in Hypertension Medscape Cardiology, February 13, 2026 QUARTET Trial -Published in The Lancet \u2022 Ultra\u2013low-dose quadpill (\u00bc standard dose each: irbesartan 37.5 mg, amlodipine 1.25 mg, indapamide 0.625 mg, bisoprolol 2.5 mg) initiated from day one in mild\u2013moderate hypertension. \u2022 QUARTET trial showed superior BP reduction [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9553","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=9553"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9553\/revisions"}],"predecessor-version":[{"id":9554,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9553\/revisions\/9554"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=9553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=9553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=9553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}