{"id":9574,"date":"2026-02-21T22:54:45","date_gmt":"2026-02-21T19:54:45","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=9574"},"modified":"2026-02-21T22:54:45","modified_gmt":"2026-02-21T19:54:45","slug":"nabil-saadeh-who-discovers-pcsk9-cholesterol-therapies","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/nabil-saadeh-who-discovers-pcsk9-cholesterol-therapies\/","title":{"rendered":"Nabil Saadeh Who Discovers PCSK9 Cholesterol Therapies"},"content":{"rendered":"<div>Nabil Saadeh Who Discovers PCSK9 Cholesterol Therapies<\/div>\n<div><\/div>\n<div>Source: Medscape<\/div>\n<div>Date: February 16, 2026<\/div>\n<div><span> \u2022 Egyptian-Canadian biochemist based\u00a0<\/span><\/div>\n<div><span> \u2022 Discovered the PCSK9 enzyme in 2003.<\/span><\/div>\n<div><span> \u2022 2025 recipient of the Great Arab Minds Award in Medicine.<\/span><\/div>\n<div><\/div>\n<div>Difference of PCSK9 Inhibitors<\/div>\n<div><span> \u2022 PCSK9 monoclonal antibodies (alirocumab, evolocumab): block circulating PCSK9 protein.<\/span><\/div>\n<div><span> \u2022 Inclisiran: reduces PCSK9 synthesis at the mRNA level.<\/span><\/div>\n<div>They inhibit the same target (PCSK9),<\/div>\n<div>but through different mechanisms<\/div>\n<div><span> \u2022 PCSK9 reduces the number of LDL receptors in the liver.<\/span><\/div>\n<div><span> \u2022 Fewer LDL receptors \u2192 higher \u201cbad\u201d LDL cholesterol in the bloodstream.<\/span><\/div>\n<div><span> \u2022 Blocking PCSK9 lowers LDL by ~50%.<\/span><\/div>\n<div><span> \u2022 Combined with statins \u2192 LDL reduction of 66\u201375%<\/span><\/div>\n<div>(vs 45\u201355% with high-intensity statins alone).<\/div>\n<div><span> \u2022 Significantly reduces heart attacks and major CV events.<\/span><\/div>\n<div><\/div>\n<div>Genetic Evidence<\/div>\n<div><span> \u2022 Overactive PCSK9 mutations \u2192 very high LDL and inherited hypercholesterolemia.<\/span><\/div>\n<div><span> \u2022 Reduced-function mutations \u2192 very low LDL and ~90% lower heart disease risk.<\/span><\/div>\n<div><\/div>\n<div>Beyond Lipids<\/div>\n<div>PCSK9 research now extends to:<\/div>\n<div><span> \u2022 Cancer<\/span><\/div>\n<div><span> \u2022 Immune system regulation<\/span><\/div>\n<div><span> \u2022 Gene therapy approaches<\/span><\/div>\n<div><\/div>\n<div><a href=\"https:\/\/www.medscape.com\/viewarticle\/nabil-seidah-discovery-led-pcsk9-cholesterol-therapies-2026a10004uk?utm_source=chatgpt.com\">https:\/\/www.medscape.com\/viewarticle\/nabil-seidah-discovery-led-pcsk9-cholesterol-therapies-2026a10004uk?utm_source=chatgpt.com<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Nabil Saadeh Who Discovers PCSK9 Cholesterol Therapies Source: Medscape Date: February 16, 2026 \u2022 Egyptian-Canadian biochemist based\u00a0 \u2022 Discovered the PCSK9 enzyme in 2003. \u2022 2025 recipient of the Great Arab Minds Award in Medicine. Difference of PCSK9 Inhibitors \u2022 PCSK9 monoclonal antibodies (alirocumab, evolocumab): block circulating PCSK9 protein. \u2022 Inclisiran: reduces PCSK9 synthesis at [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9574","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9574","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=9574"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9574\/revisions"}],"predecessor-version":[{"id":9575,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9574\/revisions\/9575"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=9574"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=9574"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=9574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}