{"id":9890,"date":"2026-04-21T17:31:11","date_gmt":"2026-04-21T14:31:11","guid":{"rendered":"https:\/\/jordan-cardiac.org\/?p=9890"},"modified":"2026-04-21T17:31:11","modified_gmt":"2026-04-21T14:31:11","slug":"paradigm-change-coming-in-secondary-stroke-prevention-oceanic-stroke-2026","status":"publish","type":"post","link":"https:\/\/jordan-cardiac.org\/en\/paradigm-change-coming-in-secondary-stroke-prevention-oceanic-stroke-2026\/","title":{"rendered":"Paradigm Change Coming in Secondary Stroke Prevention: OCEANIC-STROKE (2026)"},"content":{"rendered":"<p>Paradigm Change Coming in Secondary Stroke Prevention: OCEANIC-STROKE (2026)<\/p>\n<p>Source: Medscape -April 15, 2026(The trial presented at AHA 2026 and published in NEJM, confirming their high scientific impact beyond Medscape).<\/p>\n<p>\u2022\u2060 \u2060New class: Factor XIa inhibitor (Asundexian)<br \/>\n\u2022\u2060 \u2060Aim: reduce stroke risk with less bleeding than traditional anticoagulants<\/p>\n<p>Background<br \/>\n\u2022\u2060 \u2060Aspirin \u2192 ~15% risk reduction<br \/>\n\u2022\u2060 \u2060Anticoagulants (AF) \u2192 60\u201370% reduction but \u2191 bleeding<br \/>\nNeed: safer antithrombotic option<\/p>\n<p>Study Design<br \/>\n\u2022\u2060 \u2060~6150 patients<br \/>\n\u2022\u2060 \u2060Non-cardioembolic stroke or high-risk TIA<br \/>\n\u2022\u2060 \u2060On top of:<br \/>\n* Aspirin \u00b1 clopidogrel<br \/>\n\u2022\u2060 \u2060Compared:<br \/>\n* Asundexian 50 mg daily vs placebo<\/p>\n<p>Key Results<br \/>\n\u2022\u2060 \u2060\u2193 Ischemic stroke risk by 25% , \u2193 composite CV outcomes<br \/>\n\u2022\u2060 \u2060Benefit consistent across subgroups<\/p>\n<p>Safety<br \/>\n\u2022\u2060 \u2060No increase in major bleeding (ISTH)<br \/>\n\u2022\u2060 \u2060Similar bleeding vs placebo<\/p>\n<p>Clinical Insight<br \/>\n\ud83d\udc49 First major advance beyond aspirin in ~50 years<br \/>\n\ud83d\udc49 Effective in atherosclerotic stroke (non-cardioembolic)<br \/>\n\u2757 Not effective in AF (different mechanism)<\/p>\n<p>\ud83c\udfaf Take-home<br \/>\nAsundexian adds benefit on top of standard antiplatelet therapy without increasing bleeding<\/p>\n<p><a href=\"https:\/\/www.medscape.com\/viewarticle\/paradigm-change-coming-secondary-stroke-prevention-oceanic-2026a1000ax3\">https:\/\/www.medscape.com\/viewarticle\/paradigm-change-coming-secondary-stroke-prevention-oceanic-2026a1000ax3<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Paradigm Change Coming in Secondary Stroke Prevention: OCEANIC-STROKE (2026) Source: Medscape -April 15, 2026(The trial presented at AHA 2026 and published in NEJM, confirming their high scientific impact beyond Medscape). \u2022\u2060 \u2060New class: Factor XIa inhibitor (Asundexian) \u2022\u2060 \u2060Aim: reduce stroke risk with less bleeding than traditional anticoagulants Background \u2022\u2060 \u2060Aspirin \u2192 ~15% risk reduction [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9890","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9890","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/users\/145"}],"replies":[{"embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/comments?post=9890"}],"version-history":[{"count":1,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9890\/revisions"}],"predecessor-version":[{"id":9891,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/posts\/9890\/revisions\/9891"}],"wp:attachment":[{"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/media?parent=9890"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/categories?post=9890"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jordan-cardiac.org\/en\/wp-json\/wp\/v2\/tags?post=9890"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}