Calcium Supplements & Recurrent CVD Risk (JAHA 2026)
Calcium Supplements & Recurrent CVD Risk (JAHA 2026)
• Calcium supplements in patients with established CVD
👉 May ↑ risk of recurrent events
Study
• N = 237,000+ CVD patients
• Real-world, propensity-matched analysis
Key Findings
• ↑ Recurrent CV events (MI, stroke, CHD)
• ↑ Hospitalizations
Risk modest but consistent (~10–20%)
Critical Insight
• Calcium alone → ↑ risk (HR ~1.2)
• Calcium + Vitamin D → no increased risk
🔍 Higher Risk In
• Men
• Higher doses (≥1000 mg/day)
Mechanism (proposed)
• Transient ↑ serum calcium
• ↑ Vascular calcification
• ↑ Coagulability
Take-home
👉 Calcium supplements ≠ benign in CVD patients
👉 Avoid calcium alone
👉 If needed → combine with Vitamin D
https://www.tctmd.com/news/cvd-patients-calcium-supplements-may-spur-recurrent-events