POET II Trial | ESC 2026
POET II Trial | ESC 2026
Shorter Antibiotic Therapy Based on Clinical Response in Infective Endocarditis
• 508 endocarditis patients: tailored antibiotics 26 vs 41 days.
• Noninferior safety: 8.2% vs 10.7%.
• More relapse: 5.1% vs 1.6%, especially E. faecalis.
• Message: Selected stable patients may safely receive shorter antibiotic therapy.
• NEJM | ESC 2026.
POET II – ESC 2026 / ACC
https://www.acc.org/latest-in-cardiology/articles/2026/08/24/12/30/fri-530am-poet-ii-esc-2026