Recent studies and guidelines suggest that female sex alone may not independently increase stroke risk in atrial fibrillation (AF) patients.
Recent studies and guidelines suggest that female sex alone may not independently increase stroke risk in atrial fibrillation (AF) patients.
As of 2025, the inclusion of female sex in the CHA₂DS₂-VASc score has been re-evaluated. Consequently, a modified scoring system, CHA₂DS₂-VA, which excludes the sex category, has been proposed and is gaining acceptance. 
Key Points:
• CHA₂DS₂-VASc Score: Traditionally includes female sex as a risk factor, assigning 1 point.
• CHA₂DS₂-VA Score: A revised version that omits the sex category, focusing on other clinical risk factors. 
• Clinical Implication: The shift to CHA₂DS₂-VA aims to prevent overestimation of stroke risk in women and avoid unnecessary anticoagulation therapy.
