ACC.25 – ALLEPRE Study: Nurse-Coordinated Prevention Program Improves Outcomes and Reduces MACE Risk in High-Risk ACS Patients
ACC.25 – ALLEPRE Study: Nurse-Coordinated Prevention Program Improves Outcomes and Reduces MACE Risk in High-Risk ACS Patients
Presented at ACC.25, March 2025
Introduction and Methods:
The ALLEPRE study focused on the impact of a nurse-coordinated prevention program in patients with acute coronary syndrome (ACS) at high risk of major adverse cardiovascular events (MACE). The program aimed to assess the effects of comprehensive care, including medication adherence, exercise intensity, and overall management, compared to standard care. This multicenter, randomized controlled trial was conducted across several hospitals, with a large cohort of ACS patients who were at high risk for recurrent cardiovascular events.
Patients were assigned to either the fully nurse-coordinated prevention program (which included tailored lifestyle interventions, medication management, and exercise programs) or the standard care group, receiving usual medical treatment and follow-up. The primary endpoint was the incidence of MACE, including myocardial infarction (MI), stroke, revascularization procedures, and cardiovascular death. Secondary outcomes included medication adherence and exercise intensity levels.
Main Results:
1. Reduction in MACE Risk:
• The nurse-coordinated prevention program led to a significant reduction in MACE risk in high-risk ACS patients compared to standard care.
• Patients in the intervention group showed lower rates of recurrent MI, stroke, and cardiovascular-related events.
2. Increased Exercise Intensity:
• The intervention group demonstrated significantly greater improvements in exercise intensity and physical activity levels compared to those in the standard care group.
• Patients in the nurse-coordinated program had higher levels of physical activity, which is crucial for post-ACS recovery.
3. Improved Medication Adherence:
• The nurse-coordinated program resulted in better medication adherence. Patients in the intervention group were more likely to adhere to prescribed medications, which is known to improve long-term outcomes in ACS management.
Conclusion:
The findings suggest that enhancing care coordination and adherence to lifestyle changes and medications can lead to better long-term cardiovascular health outcomes.
Source: Presented at ACC.25, March 2025.