February 19, 2025 – Key Messages Sweetener aspartame aggravates atherosclerosis

February 19, 2025 – Key Messages Sweetener aspartame aggravates atherosclerosis :

• Aspartame and Heart Health: A new study in Cell Metabolism links aspartame consumption to increased cardiovascular risks, including atherosclerosis, insulin spikes, fatty plaques, and inflammation.

• Animal Study Findings: Mice exposed to high aspartame levels for 12 weeks showed significantly higher risks of developing arterial plaques and inflammation compared to control groups.

• Role of CX3CL1: Researchers identified the CX3CL1 protein as a key factor in plaque formation is activated by aspartame..

• Potential Implications: The study suggests that aspartame may have long-term health effects, prompting further investigation into its impact on human cardiovascular health.

• Future Research: Scientists aim to confirm these findings in human studies and explore targeting CX3CL1 to reduce vascular inflammation.

• Public Health Concern: With artificial sweeteners present in many foods, understanding their long-term impact is crucial for guiding dietary recommendations.